COMBINATION CHEMOTHERAPY (CCT) REGIMENS / MULTIPLE AGENT THERAPY (MAT): acronyms are listed in alphabetical order but unfortunately drug initials in most acronyms are not in alphabetical order.

Abbreviations :

Schedules :
vincristine
fludarabine (or other purine analog)
mitoxantrone
cyclophosph. (or other alkylating agent)
cisplatin (or other platinum compounds)
etoposide
dexamethasone or other GR agonists
doxorubicin or other anthracycline
bleomycin
MTX
araC (or other pyrimidine analog)
G-CSF
DT-PACE       4 days of IV continuous infusion 400 mg/m2/day 4 days of IV continuous infusion 10 mg/m2/day 4 days of IV continuous infusion 40 mg/m2/day 40 mg PO daily for 4 days 4 days of IV continuous infusion 10 mg/m2/day        
FLIDA           prednisone idarubicin         
FLAIG / FLAG-IDA 30 mg/m2 (25 mg/m2 in patients aged > 70 yrs) on days 1-5 idarubicin 10 mg/m2 in 24 hours continuous perfusion on days 1-3-5

OR 

12 mg/m2 on days 1-3

1 g/m

OR

2 g/m2 on days 1-5

from day 6 OR 7 until absolute neutrophil count (ANC) >500/mlref
FLANG   30 mg/m2/day on days 1-3 in 30-minute i.v. infusion 10 mg/m2/day on days 1-3 in a 30-minute infusion starting 4 hours after fludarabine               1 g/m2/day on days 1-3 in 2-hour infusion starting 4 hours after fludarabine 300 mg/day s.c. starting 12 hours before fludarabine
BEAM       melphalan 140 mg/m2BSA i.v. for 1 day

and

BCNU 300 mg/m2BSA i.v. for 1 day

  1200 mg/m2BSA i.v. for 4 days         200 mg/m2BSA twice daily i.v. for 4 days  
BU/CY       2x60 mg/kg

and

busulfan 16 mg/kg

               
PEC
P-VABEC / VACOP-B 1.2 mg/m2/day i.v. on day 1 of weeks 2, 4, 6,  8, 10, 12     350 mg/m2/day i.v. on day 1 of weeks 1, 5, 9   50 mg/m2/day i.v. on day 1 of weeks 3, 7, 11 and 100 mg/m2/day p.o. on day 2+3 of weeks 3, 7, 11 prednisone 45 mg/m2 per day po on days 1–7 of weeks  1–12 50 mg/m2/day i.v. day 1 of weeks 1, 3, 5,  7, 9, 11 10 mg/m2/day i.v. on day 1 of weeks 2, 4, 6,  8, 10, 12      
high-dose sequential (HDS) therapy       high-dose cyclophosphamide (HD-CY, 7 g/m2   high-dose etoposide (HD-VP, 2 g/m2)            
DAV                        
VAD 0.4 mg/day IV continuous infusion days 1-4           40 mg PO days 1-4, 9-12, 17-20 9 mg/m2/day IV continuous infusion days 1-4        
DHAP         100 mg/m2/day IV continuous infusion day 1   40 mg/day PO or IV days 1-4       2000 mg/m2 IV every 12 hours for 2 doses, day 2  
ESHAP         25 mg/m2/day IV continuos infusion days 1-4 (total 100 mg/m2) 40 mg/m2/day IV days 1-4 methylpredn. 250-500 mg/day IV days 1-5        2000 mg/m2 IV day 5 (give immediately following completion of etoposide and cisplatin)  
MACOP-B (round to nearest 0.1 mg) 1.4 mg/m2 IV on days 8, 22, 36, 50, 64, and 78     350 mg/m2 (round to nearest 10 mg) IV on days 1, 15, 29, 43, 57, and 71     prednisone 75 mg PO daily for 10 weeks, then taper over next 15 days (outpatient prescription in multiples of 5 mg or 50 mg tablets) 50 mg/m2 (round to nearest 1 mg) IV on days 1, 15, 29, 43, 57, and 71 10 units/m2 IV on days 22, 50, and 78 (round to nearest 1 units 100 mg/m2 IV bolus or 300 mg/m2 IV over 4 hours on days 8, 36, and 64   leucovorin 15 mg PO q6h for 6 doses, starting 24 hours after methotrexate
CHOP-14 2 mg IV day 1           prednisone 100 mg/day PO days 1-5 50 mg/m2 IV day 1       filgrastim 300 mg/day (< 75 kg) or 480 mg (>= 75 kg) subcutaneously days 4-13
3+7               idarubicin 12 mg/mBSA2/day > daunorubicin 45 mg/mBSA2/day > doxorubicin 60 mg/mBSA2, which has higher gastrointestinal toxicity, IV days 1-3     100 mg/m2/day IV continuous infusion days 1-7  
3+3+5                        
hyperCVAD                        
FND   25 mg/m2/day IV days 1-3 10 mg/m2 IV day 1       20 mg/day PO days 1-5         5 mg/kg sc starting day 8 continuing 10-14 days until ANC >= 10,000/mm3
HAM                        
IGEV vinorelbine 20 mg/m2 iv day 1) ifosfamide (+ mesna) 2 g/m2 iv on days 1-4 gemcitabine 800 mg/m2 iv days 1-4, day 1
ABVD 6 mg/m2 i.v. at day 1 and 15     dacarbazine 375 mg/m2 i.v. at day 1 and 15       25 mg/m2 i.v. at day 1 and 15 10 mg/m2 i.v. at day 1 and 15      
MOPP 1.4 mg/m2 IV days 1, 8 (maximum 2 mg)     mechlorethamine 6 mg/m2 IV days 1, 8

and 

procarbazine 100 mg/m2/day PO days 1-14

    prednisone 40 mg/m2/day PO days 1-14        
AML12                        
LAL0902                        
LAL                        


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