ADAPTIVE, ACQUIRED OR SPECIFIC IMMUNE SYSTEM

Table of contents :



 

Intracellular PAg accumulation, decreased membrane mobility of the CD277 BTN3A1 isoform, and ensuing Vg9Vd2 T-cell activationref. Upon stimulation by nonpeptidic Ags, Vg9Vd2 T cells express FcgRIIIA (CD16), a receptor that is constitutively expressed on NK cells. CD16 appears to be an activation Ag for Vg9Vd2 T cells. Indeed, ligation of CD16 on Vg9Vd2 T cells leads to TNF- production. This TNF- production, which is dependent (like that induced via the TCR-CD3 complex) on the activation of the p38 and ERK2 MAPKs, can be modulated by CD94 NK receptors. Therefore, it appears that Vg9Vd2 T cells can be physiologically activated by two sequential steps via two different cell surface Ags: the TCR-CD3 complex and the FcgRIIIA receptor, which are specific cell surface Ags for T lymphocytes and NK cells, respectively. This strongly suggests that, in the general scheme of the immune response, Vg9Vd2 T cells represent an important subpopulation of cells that play a key role in the defense against invading pathogensref

(reproduced with permission from Nature Reviews Immunology (Vol 3, No. 11, pp 890-899(2003)) copyright Macmillan Magazines Ltd)

(reproduced with permission from Nature Reviews Immunology (Vol 3, No. 11, pp 890-899(2003)) copyright Macmillan Magazines Ltd)

(reproduced with permission from Nature Reviews Immunology (Vol 3, No. 11, pp 890-899(2003)) copyright Macmillan Magazines Ltd)
Pentraxin binding to Fc?R in a 1:1 stoichiometry induces functional activation of Fc?R-mediated phagocytosis and cytokine secretionref. As the plasma concentration of CRP but not SAP may reach greater than 200 ?g/ml during the acute phaseref, the inhibition of IgG-mediated phagocytosis by CRP suggests a potential downregulation of antibody-mediated Fc?R activation by CRP in the late stage of the acute phase when an excess amount of soluble CRP is available.
Mice deficient in CB2, the Gi-coupled peripheral endocannabinoid receptor, have profound deficiencies in splenic marginal zone, peritoneal B1a cells, splenic memory CD4+ T cells, and intestinal NK cells and NKT cells. These findings partially phenocopy and extend the lymphocyte developmental disorder associated with the Gai2-/- genotype, and suggest that the endocannabinoid system is required for the formation of T and B cell subsets involved in immune homeostasisref

Copyright © 2001-2014 Daniele Focosi. All rights reserved | Terms of use | Legal notices
 About this site  | Acknowledgements  |    |    | Current link partners
Abbreviations and acronyms  |  Medical terminology  |  Add a link  |   | Softwares

This website subscribes to the
          HONcode principles of the HON Foundation. Click to verify.



 


 


 

 

PicoSearch
 


 

Search 



Search 
for 



Search Medical Dictionary 
for