HOMO SAPIENS DISEASES - MYELOPROLIFERATIVE NEOPLASMS (MPN)

Table of contents :


  • acute myeloid leukemias (AML) 
  • FAB classification
  • M0 / undifferentiated
  • M1
  • M2
  • M3 / acute promyelocytic leukemia (APL) 
  • therapy
  • M4 / myelomonocytic
  • M5 / monocytic
  • M6 / erythroleukemia
  • M7 / megakaryocytic
  • mixed lineage leukemias
  • WHO classification :
  • acute myeloid leukemia with recurrent genetic abnormalities
  • acute myeloid leukemia with multilineage dysplasia
  • acute myeloid leukemia and myelodysplastic syndromes, therapy related
  • acute myeloid leukemia, not otherwise categorized (AML-NOC)
  • laboratory examinations
  • therapy
  • prognosis
  • chronic myeloproliferative neoplasmss (CMPDs)
  • chronic myeloid leukemia 
  • laboratory examinations
  • therapy
  • prognosis
  • polycythemia vera 
  • essential thrombocytemia 
  • chronic idiopathic myelofibrosis 
  • chronic eosinophilic leukemia (CEL) (and the hypereosinophilic syndrome (HES))
  • chronic neutrophilic leukemia

  • Pathogenesis :

    => intramedullary accumulation of precursors (granular, polymorphonuclear leukocytes and their precursors predominate) => uneffective hemopoiesis => normocytic and normochromic anemia, leukocytosis with relative neutropenia, thrombocytosis with thrombocytopathy. Genetic lesion usually involves HSC : anyway naming is mainly based on predominant proliferating cell type. If WBCs are predominant it is named leukosis : when such neoplastic WBCs are found into blood, neoplasm is named myeloblastic, myeloblastic, myeloid or granulocytic leukemia / hemoblastosis, otherwise it is said to be an aleukemic or subleukemic leukosis or "leukemia" / leukopenic or aleukocythemic leukemia (total white blood cell count in the peripheral blood is either normal or below normal). Leukemias cause hyperviscosity syndrome => cyanosis

    Clinical course :


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