MAIN ADAPTER-ASSOCIATED RECEPTORS
(Click here for their signal transduction pathway)
 
adapter
adapter-associated receptor name (ligand(s))
expressed on ...
ligand(s)
agonists
antagonists
  • MyD88 
  • TIRAP / MAL (only TLR2 and TLR4)
  • TLRs ... ... ... ...
  • MyD88 
  • TRADD
  • CD121a (IL-1RI) + IL-1RAP (membrane-bound and soluble isoforms) [IL-1RAPL1, IL-1RAPL2]
  • IL-1a 
  • IL-1b 
  • IL-1RA (100-fold lesser avidity for IL-1RI than IL-1b; a 100-fold greater excess of IL-1RA over IL-1 may be necessary to inhibit biological responses to IL-1b)
  • CD121b (IL-1RII) (decoy receptor)
  • IL-1a 
  • IL-1b 
  • IL-1RA (100-fold greater avidity for IL-1RI; a 100-fold greater excess of IL-1RA over IL-1 may benecessary to inhibit biological responses to IL-1)
  • IL-1R-like 1 / T1 / ST2 Th2 lymphocytes IL-1R-like 1 ligand / ST2L
    IL-33
    IL-1R-like 2 IL-1 family, member 9
  • MyD88 
  • IL-1RAP 
  • TRADD
  • IL-18R (heterodimeric : IL-18R1 / IL1Rrp + IL-18RAP / AcPL (enhances the IL-18 binding activity of IL-18R1)) IL-1z
    IL-18
    TRADD TNFRSF1A / CD120a / p55TNFRI airway epithelium
  • TNF-a / cachectin 
  • TNF-b/ LT-a
  • Staphylococcus aureus protein Aref
  • TRADD TNFRSF1B / CD120b / p75TNFRII
  • TNF-a / cachectin 
  • TNF-b/ LT-a
  • TNFRSF3 / LTbR most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes
  • LT-a2LT-b heterotrimers
  • LIGHT / TL5
  • TNFRSF4 / CD134 / OX40 T lymphocytes CD134L / OX40L
    TNFRSF5 / CD40 (2 isoforms) B lymphocytes membrane-bound or soluble CD154 / 40L
    TNFRSF6 / CD95 / Apo1 / Fas (8 mRNAs => 7 isoforms: those the TM domain may negatively regulate the apoptosis mediated by the full length isoform) neutrophils, activated T cells (excepted when RA-treated), cardiomyocytes CD178 / FasL
    TNFRSF6B / DcR3 / TRAIL-R6 (a, b, c, and d  isoforms : a, b, and c are related to RAD3/ERCC2, a plasma membrane Ras-related GTPase, while the latter is a decoy receptor) activated T lymphocytes
  • membrane-bound or soluble CD178 / FasL 
  • LIGHT / TL5 
  • TL1A
  • TNFRSF7 / CD27 CD27L
    CD27BP / SIVA
    TNFRSF8 / CD30 / Ki-1 Ag (2 isoforms) activated, but not by resting, T and B cells CD153 / 30L
    TNFRSF9 / CD137 / 4-1BB peripheral monocytes, T cells CD137L / 4-1BBL
    TNFRSF10A / DR4 / TRAIL-R1 / Apo-2 transformed cells TRAIL
    TNFRSF10B / DR5 / TRAIL-R2 : 2 isoforms transformed cells
  • TRAIL 
  • LIGHT / TL5
  • TNFRSF10C / DcR1  / TRAIL-R3 many normal tissues but not in most cancer cell lines TRAIL
    TNFRSF10D / DcR2 / TRAIL-R4 ? TRAIL
    TNFRSF11A / RANK / TRANCER osteoclast progenitor cells, T cells  OPG-L / RANK-L / ODF
    TNFRSF11B / OPG (synthesis is up-regulated by 17bE2) soluble decoy receptor released from stromal cells/osteoblasts
  • TRAIL 
  • OPG-L / RANK-L / ODF
  • TNFRSF12A / FN14 / TWEAKR TWEAK
    TNFRSF13B / TACI B lymphocytes 
    activated T lymphocytes
  • membrane-bound or soluble BLys / BAFF / THANK / TALL-1 / zTNF4 
  • APRIL / TALL-2
  • TNFRSF13C / BAFF-R / BR3 B lymphocytes membrane-bound or soluble BLys / BAFF / THANK / TALL-1 / zTNF4
    TNFRSF14 / HVEM / TR2 / LIGHTR ?
  • LT-b 
  • gD of HSV 
  • LIGHT / TL5
  • B and T lymphocyte attenuator (BTLA)
  • TNFRSF16 / p75NTR neurons NGF
    rabies virus glycoprotein (RVG)
    TNFRSF17 / BCMA B lymphocytes
  • membrane-bound or soluble BLys / BAFF / THANK / TALL-1 / zTNF4 
  • APRIL / TALL-2
  • TNFRSF18 / AITR / GITR / GITR-D; 3 isoforms activated T cells AITRL / GITRL
    TNFRSF19 / TAJ /  TROY /  TRADE /  TAJ-alpha ; 2 isoforms highly expressed during embryonic development
    TRADD TNFRSF21 / DR6 / BM-018 ?
    TNFRSF22 / SOBa / Tnfrh2 / 2810028K06Rik
    TNFRSF23 / mSOB / Tnfrh1
    TNFRSF25 / DR3 / TR3 / DDR3 / LARD / APO-3 / TRAMP / WSL-1 / WSL-LR / TNFRSF12 ; 11 isoforms expressed preferentially in the tissues enriched in lymphocytes TL1A
    EDAR ectodysplasin A isoform 1 (EDA1)
    XEDAR ectodysplasin A isoform 2 (EDA2)
    CD28 / Tp44 T lymphocytes
  • B7.1 / CD80 
  • B7.2 / B70 / CD86
  • CD152 / CTLA-4 cytotoxic T-lymphocyte
  • B7.1 / CD80 
  • B7.2 / B70 / CD86
  • Web resources :


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