Publications


Iser IC, Lenz G, Wink MR.

EMT-like process in glioblastomas and reactive astrocytes.

Neurochemistry International, v. 122, p. 139-143, 2019.

doi: 10.1016/j.neuint.2018.11.016


Mayer R, Thome MP, Lenz G, Zanotto A.

Late autophagy inhibitor chloroquine improves efficacy of the histone deacetylase inhibitor SAHA and temozolomide in gliomas.

Biochemical Pharmacology, v. 163, p. 440-450, 2019.

doi: 10.1016/j.bcp.2019.03.015


Beckenkamp LR, Iser IC, Onzi GR, Fontoura DM, Bertoni APS, Sévigny J, Lenz G, Wink MR.

Characterization of soluble CD39 (SolCD39/NTPDase1) from Piggy-Bac nonviral system as a tool to control the nucleotides level.

Biochemical Journal, v. 476, p. BCJ20190040-1651, 2019.

doi: 10.1042/BCJ20190040


Villodre ES, Felipe KB, Oyama M, Oliveira F, da Costa Lopez PL, Solari C, Slevender G, Guberman A, Lenz G.

Silencing of the transcription factors Oct4, Sox2, Klf4, c-Myc or Nanog has different effect on teratoma growth.

Biochemical and Biophysical Research Communications, v. 517, p. 324-329, 2019.

doi: 10.1016/j.bbrc.2019.07.064


Thome MP, Pereira LC, Onzi GR, Rohden F, Ilha M, Guma FT, Wink MR, Lenz G.

Dipyridamole impairs autophagic flux and exerts antiproliferative activity on prostate cancer cells.

Experimental Cell Research, v. 382, p. 111456-111466, 2019.

doi: 0.1016/j.yexcr.2019.06.001


Minussi D.C., Henz B., Oliveira M.S., Filippi-Chiela E.C., Oliveira M.M., Lenz G.

esiCancer: Evolutionary in silico Cancer Simulator.

Cancer Research, v. 79(5), p. 1010-1013, 2019.

doi: 10.1158/0008-5472.CAN-17-3924.


Ulasov IV, Lenz G, Lesniak M.

Autophagy in glioma cells: An identity crisis with a clinical perspective.

Cancer Letters, . 428, p. 139-146, 2018.

doi: 10.1016/j.canlet.2018.04.034


Kipper FC, Tamajusuku ASK, Minussi DC, Vargas JE, Battastini AMO, Kaczmarek E, Robson SC, Lenz G, Wink MR.

Analysis of NTPDase2 in the cell membrane using fluorescence recovery after photobleaching (FRAP).

Cytometry Part A, v. 93, p. 232-283, 2018.

doi: 10.1002/cyto.a.23317


Pereira MB, Barros LRC, Bracco PA, Vigo A, Boroni M, Bonamigo MH, Lenz G.

Transcriptional characterization of immunological infiltrates and their relation with glioblastoma patients overall survival.

OncoImmunology, v. 1, n. e1431083, 2018.

doi: 10.1080/2162402X.2018.1431083


Villodre ES, Kipper FC, Silva AO, Da Costa Lopez PL, Lenz G.

Low Dose of Doxorubicin Potentiates the Effect of Temozolomide in Glioblastoma Cells.

Molecular Neurobiology, v. 55, p. 4185-4194, 2018.

doi: 10.1007/s12035-017-0611-6


Melo-Hanchuk TD, Slepicka PF, Meirelles GV, Basei FL, Lovato DV, Granato DC, Pauletti BA, Domingues RR, Leme AFP, Pelegrini AL, Lenz G, Knapp S, Elkins JM, Kobarg J.

NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin.

Scientific Reports, v. 7, n. 5445, 2017.

doi: 10.1038/s41598-017-05325-w


de Andrade Mello P, Bian S, Savio LEB, Zhang H, Zhang J, Junger W, Wink MR, Lenz G, Buffon A, Wu Y, Robson SC.

Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death.

Oncotarget, v. 8, p. 67254-67268, 2017.

doi: 10.18632/oncotarget.18595


Ledur PF, Onzi GR, Zong H, Lenz G.

Culture conditions defining glioblastoma cells behavior: what is the impact for novel discoveries?.

Oncotarget, v. 8, p. 69185-69197, 2017.

doi: 10.18632/oncotarget.20193


Iser IC, Pereira MB, Lenz G, Wink MR.

The Epithelial-to-Mesenchymal Transition-Like Process in Glioblastoma: An Updated Systematic Review and In Silico Investigation.

Medicinal Research Reviews, v. 37, p. 271-313, 2017.

doi: 10.1002/med.21408


Salton GD, Laurino CCFC, Mega NO, Delgado-Cañedo A, Setterblad N, Carmagnat M, Xavier RM, Cirne-Lima E, Lenz G, Henriques JAP, Laurino JP.

Deletion of eIF2β lysine stretches creates a dominant negative that affects the translation and proliferation in human cell line: A tool for arresting the cell growth.

Cancer Biology & Therapy, v. 18, p. 560-570, 2017.

doi: 10.1080/15384047.2017.1345383


Kipper FC, Silva AO, Marc AL, Confortin G, Junqueira AV, Neto EP, Lenz G.

Vinblastine and antihelmintic mebendazole potentiate temozolomide in resistant gliomas.

Investigational New Drugs, v. 36, p. 323-331, 2017.

doi: 10.1007/s10637-017-0503-7


Menegotto PR, da Costa Lopez PL, Souza BK, de Farias CB, Filippi-Chiela EC, Vieira IA, Schwartsmann G, Lenz G, Roesler R.

Gastrin-Releasing Peptide Receptor Knockdown Induces Senescence in Glioblastoma Cells.

Molecular Neurobiology, v. 54, p. 888-894, 2017.

doi: 10.1007/s12035-016-9696-6


Klionsky, DJ et al

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Autophagy (Georgetown, TX), v. 12, p. 1-222, 2016.

doi: 10.1080/15548627.2015.1100356.


Ledur PF, Liu C, He H, Harris AR, Minussi DC, Zhou HY, Shaffrey ME, Asthagiri A, Lopes MB, Schiff D, Lu YC, Mandell JW, Lenz G, Zong H.

Culture conditions tailored to the cell of origin are critical for maintaining native properties and tumorigenicity of glioma cells.

Neuro-Oncology, v. 18, p. 1413-1424, 2016.

doi: 10.1093/neuonc/now062


Onzi GR, Ledur PF, Hainzenreder LD, Bertoni AP, Silva AO, Lenz G, Wink MR.

Analysis of the safety of mesenchymal stromal cells secretome for glioblastoma treatment.

Cytotherapy (Oxford), v. 18, p. 828-837, 2016.

doi: 10.1016/j.jcyt.2016.03.299


Filippi-Chiela EC, Viegas MS, Thomé MP, Buffon A, Wink MR, Lenz G.

Modulation of Autophagy by Calcium Signalosome in Human Disease.

Molecular Pharmacology, v. 90, p. 371-384, 2016.

doi: 10.1124/mol.116.105171


Silva AO, Dalsin E, Onzi GR, Filippi-Chiela EC, Lenz G.

The regrowth kinetic of the surviving population is independent of acute and chronic responses to temozolomide in glioblastoma cell lines.

Experimental Cell Research, v. 348, p. 177-183, 2016.

doi: 10.1016/j.yexcr.2016.09.014


Villodre ES, Kipper FC, Pereira MB, Lenz G.

Roles of OCT4 in tumorigenesis, cancer therapy resistance and prognosis.

Cancer Treatment Reviews, v. 51, p. 1-9, 2016.

doi: 10.1016/j.ctrv.2016.10.003


Silva AO, Felipe KB, Villodre ES, Lopez PL, Lenz G.

A guide for the analysis of long-term population growth in cancer.

Tumor Biology, v. 37, p. 13743-13749, 2016.

doi: 10.1007/s13277-016-5255-z


Thomé MP, Filippi-Chiela EC, Villodre ES, Migliavaca CB, Onzi GR, Felipe KB, Lenz G.

Ratiometric analysis of acridine orange staining in the study of acidic organelles and autophagy.

Journal of Cell Science, v. 129, p. 4622-4632, 2016.

doi: 10.1242/jcs.195057


Iser IC, Ceschini SM, Onzi GR, Bertoni AP, Lenz G, Wink MR.

Conditioned Medium from Adipose-Derived Stem Cells (ADSCs) Promotes Epithelial-to-Mesenchymal-Like Transition (EMT-Like) in Glioma Cells In vitro.

Molecular Neurobiology, v. 53, p. 7184-7199, 2016.

doi: 10.1007/s12035-015-9585-4


Gaelzer MM, Santos MSD, Coelho BP, de Quadros AH, Simão F, Usach V, Guma FCR, Setton-Avruj P, Lenz G, Salbego CG.

Hypoxic and Reoxygenated Microenvironment: Stemness and Differentiation State in Glioblastoma.

Molecular Neurobiology, v. 54, p. 6261-6272, 2016.

doi: 10.1007/s12035-016-0126-6


Filippi-Chiela EC, Bueno e Silva MM, Thomé MP, Lenz G.

Single-cell analysis challenges the connection between autophagy and senescence induced by DNA damage.

Autophagy (Georgetown, TX), v. 11, p. 1099-1113, 2015.

doi: 10.1080/15548627.2015.1009795


Gehring MP, Kipper F, Nicoletti NF, Sperotto ND, Zanin R, Tamajusuku AS, Flores DG, Meurer L, Roesler R, Filho AB, Lenz G, Campos MM, Morrone FB.

P2X7 receptor as predictor gene for glioma radiosensitivity and median survival.

International Journal of Biochemistry & Cell Biology, v. 68, p. 92-100, 2015.

doi: 10.1016/j.biocel.2015.09.001


Solari C, Vázquez Echegaray C, Cosentino MS, Petrone MV, Waisman A, Luzzani C, Francia M, Villodre E, Lenz G, Miriuka S, Barañao L, Guberman A.

Manganese Superoxide Dismutase Gene Expression Is Induced by Nanog and Oct4, Essential Pluripotent Stem Cells? Transcription Factors.

Plos One, v. 10, n. e0144336, 2015.

doi: 10.1371/journal.pone.0144336


Beckenkamp A, Santana DB, Bruno AN, Calil LN, Casali EA, Paccez JD, Zerbini LF, Lenz G, Wink MR, Buffon A.

Ectonucleotidase expression profile and activity in human cervical cancer cell lines.

Biochemistry and Cell Biology (Print), v. 92, p. 95-104, 2014.

doi: 10.1139/bcb-2013-0051


Zamin LL, Filippi-Chiela EC, Vargas J, Demartini DR, Meurer L, Souza AP, Bonorino C, Salbego C, Lenz G.

Quercetin promotes glioma growth in a rat model.

Food and Chemical Toxicology, v. 63, p. 205-211, 2014.

doi: 10.1016/j.fct.2013.11.002


Pereira MS, Zenki K, Cavalheiro MM, Thomé CC, Filippi-Chiela EC, Lenz G, de Souza DO, de Oliveira DL.

Cellular Senescence Induced by Prolonged Subculture Adversely Affects Glutamate Uptake in C6 Lineage.

Neurochemical Research, v. 39, p. 973-984, 2014.

doi: 10.1007/s11064-014-1295-1


Iser IC, Bracco PA, Gonçalves CE, Zanin RF, Nardi NB, Lenz G, Battastini AM, Wink MR.

Mesenchymal Stem Cells From Different Murine Tissues Have Differential Capacity to Metabolize Extracellular Nucleotides.

Journal of Cellular Biochemistry (Print), v. 115, p. 1673-1682, 2014.

doi: 10.1002/jcb.24830


Vargas JE, Filippi-Chiela EC, Suhre T, Kipper FC, Bonatto D, Lenz G.

Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells.

Biochemistry and Cell Biology (Print), v. 92, p. 297-304, 2014.

doi: 10.1139/bcb-2014-0022


Mello Pde A, Filippi-Chiela EC, Nascimento J, Beckenkamp A, Santana DB, Kipper F, Casali EA, Nejar Bruno A, Paccez JD, Zerbini LF, Wink MR, Lenz G, Buffon A.

Adenosine uptake is the major effector of extracellular ATP toxicity in human cervical cancer cells.

Molecular Biology of the Cell, v. 25, p. 2891-3093, 2014.

doi: 10.1091/mbc.E14-01-0042


Izetti P, Hautefeuille A, Abujamra AL, de Farias CB, Giacomazzi J, Alemar B, Lenz G, Roesler R, Schwartsmann G, Osvaldt AB, Hainaut P, Ashton-Prolla P.

PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines.

Investigational New Drugs, v. 32, p. 783-794, 2014.

doi: 10.1007/s10637-014-0090-9


Filippi-Chiela EC, Thomé MP, Bueno e Silva MM, Pelegrini AL, Ledur PF, Garicochea B, Zamin LL, Lenz G.

Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells.

BMC Cancer (Online), v. 13, p. 147-157, 2013.

doi: 0.1186/1471-2407-13-147


Filippi-Chiela EC, Vessoni AT, Menck CFM, Lenz G.

Autophagy and genomic integrity.

Cell Death and Differentiation, v. 20, p. 1444-1454, 2013.

doi: 10.1038/cdd.2013.103


Bordin DL, Lima M, Lenz G, Saffi J, Meira LB, Mésange P, Soares DG, Larsen AK, Escargueil AE, Henriques JA.

DNA Alkylation Damage and Autophagy Induction.

Mutation Research/Reviews in Mutation Research (Print), v. 753, p. 91-00, 2013.

doi: 10.1016/j.mrrev.2013.07.001


de Oliveira CB, Comunello LN, Maciel ES, Giubel SR, Bruno AN, Chiela EC, Lenz G, Gnoatto SC, Buffon A, Gosmann G.

The Inhibitory Effects of Phenolic and Terpenoid Compounds from Baccharis trimera in Siha Cells: Differences in Their Activity and Mechanism of Action.

Molecules (Basel. Online), v. 18, p. 11022-11032, 2013.

doi: 10.3390/molecules180911022


Bueno e Silva MM, Filippi-Chiela E, Lenz G.

Recent Patents on Morphometric Analysis of Eukaryotic Cells.

Recent Patents on Medical Imaging, v. 3, p. 123-134, 2013.

doi: 10.2174/18776132113036660014


Nör C, Sassi FA, de Farias CB, Schwartsmann G, Abujamra AL, Lenz G, Brunetto AL, Roesler R.

The Histone Deacetylase Inhibitor Sodium Butyrate Promotes Cell Death and Differentiation and Reduces Neurosphere Formation in Human Medulloblastoma Cells.

Molecular Neurobiology, v. 48, p. 533-543, 2013.

doi: 10.1007/s12035-013-8441-7


Yuahasi KK, Demasi MA, Tamajusuku AS, Lenz G, Sogayar MC, Fornazari M, Lameu C, Nascimento IC, Glaser T, Schwindt TT, Negraes PD, Ulrich H.

Regulation of neurogenesis and gliogenesis of retinoic acid-induced P19 embryonal carcinoma cells by P2X2 and P2X7 receptors studied by RNA interference.

International Journal of Developmental Neuroscience, v. 30, p. 91-97, 2012.

doi: 10.1016/j.ijdevneu.2011.12.010


Vargas J, Feltes BC, Poloni Jde F, Lenz G, Bonatto D.

Senescence: an endogenous anticancer mechanism.

Frontiers in Bioscience, v. 17, p. 2616-2643, 2012.

doi: 10.2741/4074


Lopez PL, Filippi-Chiela EC, Silva AO, Cordero EA, Garcia-Santos D, Pelegrini AL, Reder GM, Barbieri NL, Lenz G.

Sensitization of Glioma Cells by X-Linked Inhibitor of Apoptosis Protein Knockdown.

Oncology (Basel), v. 83, p. 75-82, 2012.

doi: 10.1159/000337978


Lenz G.

Endogenous anticancer mechanisms (EACMs).

Frontiers in Bioscience (Print), v. S4, p. 1017-1030, 2012.

PMID: 22202106


Ledur PF, Villodre ES, Paulus R, Cruz LA, Flores DG, Lenz G.

Extracellular ATP reduces tumor sphere growth and cancer stem cell population in glioblastoma cells.

Purinergic Signalling (Print), v. 8, p. 39-48, 2012.

doi: 10.1007/s11302-011-9252-9


Mielcke TR, Mascarello A, Filippi-Chiela E, Zanin RF, Lenz G, Leal PC, Chiaradia LD, Yunes RA, Nunes RJ, Battastini AM, Morrone FB, Campos MM.

Activity of novel quinoxaline-derived chalcones on in vitro glioma cell proliferation.

European Journal of Medicinal Chemistry, v. 48, p. 255-264, 2012.

doi: 10.1016/j.ejmech.2011.12.023


Gehring MP, Pereira TC, Zanin RF, Borges MC, Braga Filho A, Battastini AM, Bogo MR, Lenz G, Campos MM, Morrone FB.

P2X7 receptor activation leads to increased cell death in a radiosensitive human glioma cell line.

Purinergic Signalling (Print), v. 8, p. 729-739, 2012.

doi: 10.1007/s11302-012-9319-2


Vargas JE, Salton G, Sodré de Castro Laino A, Pires TD, Bonamino M, Lenz G, Delgado-Cañedo A.

pLR: A lentiviral backbone series to stable transduction of bicistronic genes and exchange of promoters.

Plasmid (San Diego. Print), v. 68, p. 179-185, 2012.

doi: 10.1016/j.plasmid.2012.06.001


Filippi-Chiela EC, Oliveira MM, Jurkovski B, Callegari-Jacques SM, da Silva VD, Lenz G.

Nuclear Morphometric Analysis (NMA): Screening of Senescence, Apoptosis and Nuclear Irregularities.

Plos One, v. 7, n. e42522, 2012.

doi: 10.1371/journal.pone.0042522


Andrade, CMB, Lopez, PLC, Noronha, BT, Wink, MR, Borojevic, R, Margis, R, Lenz, G, Battastini, AMO, Guma, FCR

Ecto-5'-nucleotidase/CD73 knockdown increases cell migration and mRNA level of collagen I in a hepatic stellate cell line.

Cell and Tissue Research (Print), v. 344, p. 279-286, 2011.

doi: 10.1007/s00441-011-1140-7


Filippi-Chiela EC, Villodre, ES, Zamin, LL, Lenz, G

Autophagy Interplay with Apoptosis and Cell Cycle Regulation in the Growth Inhibiting Effect of Resveratrol in Glioma Cells.

Plos One, v. 6, n. e20849, 2011.

doi: 10.1371/journal.pone.0020849


Horn AP, Bernardi A, Luiz Frozza R, Grudzinski PB, Hoppe JB, de Souza LF, Chagastelles P, de Souza Wyse AT, Bernard EA, Battastini AM, Campos MM, Lenz G, Nardi NB, Salbego C.

Mesenchymal Stem Cell-Conditioned Medium Triggers Neuroinflammation and Reactive Species Generation in Organotypic Cultures of Rat Hippocampus.

Stem Cells and Development, v. 20, p. 1171-1180, 2011.

doi: 10.1089/scd.2010.0157


Tamajusuku AS, Villodre ES, Paulus R, Coutinho-Silva R, Battasstini AM, Wink MR, Lenz G.

Characterization of ATP-induced cell death in the GL261 mouse glioma.

Journal of Cellular Biochemistry (Print), v. 109, p. 983-991, 2010.

doi: 10.1002/jcb.22478


Flores DG, Meurer L, Uberti AF, Macedo BR, Lenz G, Brunetto AL, Schwartsmann G, Roesler R.

Gastrin-releasing peptide receptor content in human glioma and normal brain.

Brain Research Bulletin, v. 82, p. 95-98, 2010.

doi: 10.1016/j.brainresbull.2010.02.014


Moura, DJ, Castilhos, B, Immich, BF, Cañedo, AD, Henriques, JAP, Lenz, G, SAFFI, J

Kin3 protein, a NIMA-related kinase of Saccharomyces cerevisiae , is involved in DNA adduct damage response.

Cell Cycle, v. 9, p. 2220-2229, 2010.

doi: 10.4161/cc.9.11.11892


Pelegrini AL, Moura DJ, Brenner BL, Ledur PF, Maques GP, Henriques JA, Saffi J, Lenz G.

Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest.

Mutagenesis, v. 25, p. 447-454, 2010.

doi: 10.1093/mutage/geq026


Lenz G.

Transient oncogenes.

Medical Hypotheses, v. 75, p. 660-662, 2010.

doi: 10.1016/j.mehy.2010.08.012


de Oliveira MS, Cechim G, Braganhol E, Santos DG, Meurer L, de Castro CG Jr, Brunetto AL, Schwartsmann G, Battastini AM, Lenz G, Roesler R.

Anti-proliferative effect of the gastrin-release peptide receptor antagonist RC-3095 plus temozolomide in experimental glioblastoma models.

Journal of Neuro-Oncology, v. 93, p. 191-201, 2009.

doi: 10.1007/s11060-008-9775-2


Braganhol E, Morrone FB, Bernardi A, Huppes D, Meurer L, Edelweiss MI, Lenz G, Wink MR, Robson SC, Battastini AM.

Selective NTPDase2 expression modulates in vivo rat glioma growth.

Cancer Science, v. 100, p. 1434-1442, 2009.

doi: 10.1111/j.1349-7006.2009.01219.x


Zamin LL, Filippi-Chiela EC, Dillenburg-Pilla P, Horn F, Salbego C, Lenz G.

Resveratrol and Quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells.

Cancer Science, v. 100, p. 1655-1662, 2009.

doi: 10.1111/j.1349-7006.2009.01215.x


Flores DG, Lenz G, Roesler R, Schwartsmann G

Gastrin-releasing peptide receptor signaling in cancer.

Cancer Therapy, v. 7, p. 332-346, 2009.


Flores DG, Ledur PF, Abujamra AL, Brunetto AL, Schwartsmann G, Lenz G, Roesler R.

Cancer Stem Cells and the Biology of Brain Tumors.

Current Stem Cell Research and Therapy, v. 4, p. 306-313, 2009.

doi: 10.2174/157488809789649214


Spiller F, Morrone FB, Engroff P, Edelweiss MI, Meurer L, Barros C, Azambuja AA, Oliveira DL, Lenz G, Battastini AMO.

Effect of temozolomide treatment on the adenine nucleotide hydrolysis in blood serum of rats with implanted gliomas.

Applied Cancer Research (Online), v. 29, p. 117-123, 2009.


Lanza DC, Meirelles GV, Alborghetti MR, Abrile CH, Lenz G, Kobarg J.

FEZ1 interacts with CLASP2 and NEK1 through coiled-coil regions and their cellular colocalization suggests centrosomal functions and regulation by PKC.

Molecular and Cellular Biochemistry, v. 338, p. 35-45, 2009.

doi: 10.1007/s11010-009-0317-9


Gerhardt D, Horn AP, Gaelzer MM, Frozza RL, Delgado-Cañedo A, Pelegrini AL, Henriques AT, Lenz G, Salbego C.

Boldine: a potential new antiproliferative drug against glioma cell lines.

Investigational New Drugs, v. 27, p. 517-525, 2009.

doi: 10.1007/s10637-008-9203-7


Flores DG, de Farias CB, Leites J, de Oliveira MS, Lima RC, Tamajusuku AS, Di Leone LP, Meurer L, Brunetto AL, Schwartsmann G, Lenz G, Roesler R.

Gastrin-Releasing Peptide Receptors Regulate Proliferation of C6 Glioma Cells through a Phosphatidylinositol 3-Kinase-Dependent Mechanism.

Current Neurovascular Research, v. 5, p. 99-105, 2008.

doi: 10.2174/156720208784310240


Horn AP, Frozza RL, Grudzinski PB, Gerhardt D, Hoppe JB, Bruno AN, Chagastelles P, Nardi NB, Lenz G, Salbego C.

Conditioned medium from mesenchymal stem cells induces cell death in organotypic cultures of rat hippocampus and aggravates lesion in a model of oxygen and glucose deprivation.

Neuroscience Research, v. 63, p. 35-41, 2008.

doi: 10.1016/j.neures.2008.10.001


Braganhol E, Huppes D, Bernardi A, Wink MR, Lenz G, Battastini AM.

A comparative study of ectonucleotidase and P2 receptor mRNA profiles in C6 cell line cultures and C6 ex vivo glioma model.

Cell and Tissue Research, v. 335, p. 331-340, 2008.

doi: 10.1007/s00441-008-0723-4


Bernardi A, Bavaresco L, Wink MR, Jacques-Silva MC, Delgado-Cañedo A, Lenz G, Battastini AM.

Indomethacin stimulates activity and expression of ecto-5′-nucleotidase/CD73 in glioma cell lines.

European Journal of Pharmacology, v. 569, p. 8-15, 2007.

doi: 10.1016/j.ejphar.2007.04.058


Wink MR, Braganhol E, Tamajusuku AS, Lenz G, Zerbini LF, Libermann TA, Sévigny J, Battastini AM, Robson SC.

Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes.

Neuroscience, v. 138, n.2, p. 421-432, 2006.

doi: 10.1016/j.neuroscience.2005.11.039


Bernardi A, Jacques-Silva MC, Delgado-Cañedo A, Lenz G, Battastini AM.

Nonsteroidal anti-inflammatory drugs inhibit the growht of C6 and U138-MG glioma cell lines.

European Journal of Pharmacology, v. 532, n.3, p. 214-222, 2006.

doi: 10.1016/j.ejphar.2006.01.008


Morrone FB, Oliveira DL, Gamermann P, Stella J, Wofchuk S, Wink MR, Meurer L, Edelweiss MI, Lenz G, Battastini AM.

In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model.

BMC Cancer (Online), v. 6, n. 226, 2006.

doi: 10.1186/1471-2407-6-226


Morrone FB, Horn AP, Stella J, Spiller F, Sarkis JJ, Salbego CG, Lenz G, Battastini AM.

Increased resistance of glioma cell lines to extracellular ATP cytotoxicity.

Journal of Neuro-Oncology, USA, v. 71, p. 135-140, 2005.

doi: 10.1007/s11060-004-1383-1


Horn AP, Gerhardt D, Geyer AB, Valentim L, Cimarosti H, Tavares A, Horn F, Lenz G, Salbego C.

Cellular death in hippocampus in response to PI3K pathway inhibition and oxygen and glucose deprivation.

Neurochemical Research, Estados Unidos, v. 30, n.3, p. 355-361, 2005.

doi: 10.1007/s11064-005-2609-0


Souza LF, Horn AP, Gelain DP, Jardim FR, Lenz G, Bernard EA.

Extracellular inosine modulates ERK ½ and p38 phosphorylation in cultured Sertoli cells: possible participation in TNF-alpha modulation of ERK ½.

Life Sciences, Holanda, v. 77, p. 3117-3126, 2005.

doi: 10.1016/j.lfs.2005.05.049


Lenz G.

The RNA interference revolution.

Brazilian Journal of Medical and Biological Research (Impresso), Brasil, v. 38, p. 1749-1757, 2005.

doi: 10.1590/S0100-879X2005001200003


Lenz G, Avruch J.

Glutamatergic regulation of the p70S6 Kinase in primary mouse neurons.

The Journal of Biological Chemistry, Estados Unidos da America, v. 280, n.46, p. 38121-38124, 2005.

doi: 10.1074/jbc.C500363200


Jacques-Silva MC, Rodnight R, Lenz G, Liao Z, Kong Q, Tran M, Kang Y, Gonzalez FA, Weisman GA, Neary JT.

P2X7 receptors stimulate Akt phosphorylation in astrocytes.

British Journal of Pharmacology, Inglaterra, v. 141, p. 1106-1117, 2004.

doi: 10.1038/sj.bjp.0705685


Jacques-Silva MC, Bernardi A, Rodnight R, Lenz G.

ERK, PKC and PI3K/Akt pathways mediate extracellular ATP and adenosine-induced proliferation of U138-MG glioma cell line.

Oncology (Basel), Suica, v. 67, n.5-6, p. 450-459, 2004.

doi: 10.1159/000082930


Morrone FB, Jacques-Silva MC, Horn AP, Bernardi A, Schwartsmann G, Rodnight R, Lenz G.

Extracellular nucleotides and nucleosides induce proliferation and increase nucleoside transport in human glioma cell lines.

Journal of Neuro-Oncology, USA, v. 64, p. 211-218, 2003.

doi: 10.1023/A:1025699932270


Wink MR, Lenz G, Braganhol E, Tamajusuku AS, Schwartsmann G, Sarkis JJ, Battastini AM.

Altered extracellular ATP, ADP and AMP catabolism in glioma cell lines.

Cancer Letters (Print), v. 198, p. 211-218, 2003.

doi: 10.1016/S0304-3835(03)00308-2


Lenz G, Gonçalves D, Luo Z, Avruch J, Rodnight R, Neary JT.

Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures.

Journal of Neurochemistry, Inglaterra, v. 77, n.4, p. 1001-1009, 2001.

doi: 10.1046/j.1471-4159.2001.00299.x


Neary JT, Lenz G, Kang Y, Rodnight R, Avruch J.

Role of Mitogen-Activated Protein Kinase Cascadesin P2Y Receptor-Mediated Trophic Activationof Astroglial Cells.

Drug Development Research, Estados Unidos, v. 53, n.2-3, p. 158-165, 2001.

doi: 10.1002/ddr.1183


Barros DM, Mello e Souza T, de Souza MM, Choi H, DeDavid e Silva T, Lenz G, Medina JH, Izquierdo I.

LY294002, an inhibitor of phosphoinositide 3-kinase given into rat hippocampus impairs acquisition, consolidation and retrieval of memory for one-trial step-down inhibitory avoidance.

Behavioral Pharmacology, Estados Unidos, v. 12, p. 629-634, 2001.

PMID: 11856900


Walz R, Lenz G, Roesler R, Vianna MM, Martins V, Brentani R, Rodnight R, Izquierdo I.

Time-dependent enhancement of inhibitory avoidance retention and MAPK activation by post-training infusion of nerve growth factor into CA1 region of hippocampus of adult rats.

European Journal of Neuroscience, Inglaterra, v. 12, n.6, p. 2185-2189, 2000.

doi: 10.1046/j.1460-9568.2000.00123.x


Gonçalves DS, Lenz G, Karl J, Gonçalves CA, Rodnight R.

Extracellular S100B Protein Modulates ERK in Astrocyte Cultures.

NeuroReport (Oxford), v. 11, p. 807-809, 2000.

PMID: 10757524


da Rocha AB, Mans DR, Lenz G, Fernandes AK, de Lima C, Monteiro VF, Gonçalves D, Moreira JC, Brunetto AL, Rodnight R, Schwartsmann G.

Protein Kinase C-Mediated in vitro invasion of Human Glioma Cells through Extracellular-Signal-Regulated Kinase and Ornithine Decarboxylase.

Invasion And Metastasis, v. 68, n.3, p. 113-123, 2000.

doi: 10.1159/000055911


Wink MR, Lenz G, Rodnight R, Sarkis JJ, Battastini AM.

Identification of brain ecto-apyrase as a phosphoprotein.

Molecular and Cellular Biochemistry, v. 213, n.1/2, p. 11-16, 2000.

doi: 10.1023/A:1007194229587


Lenz G, Gottfried C, Luo Z, Avruch J, Rodnight R, Nie WJ, Kang Y, Neary JT.

P2Y Purinergic Receptor Subtypes Recruit Different MEK Activators In Astrocytes.

British Journal of Pharmacology, v. 129, p. 927-936, 2000.

doi: 10.1038/sj.bjp.0703138


Walz R, Roesler R, Quevedo J, Rockenbach IC, Amaral OB, Vianna MR, Lenz G, Medina JH, Izquierdo I.

Dose-dependent impairment of inhibitory avoidance retention in rats by immediate posttraining infusion of a mitogen-activated protein kinase kinase inhibitor into cortical structures.

Behavioural Brain Research, v. 105, p. 219-223, 1999.

doi: 10.1016/S0166-4328(99)00077-7


Lenz G, Manozzo L, Gottardo S, Achaval M, Salbego C, Rodnight R.

Temporal profiles of the in vitro phosphorylation rate and immunocontent of glial fibrillary acidic protein (GFAP) after kainic acid-induced lesions in area CA1 of the rat hippocampus: Demonstration of a novel phosphoprotein associated with gliosis.

Brain Research, v. 764, p. 188-196, 1997.

doi: 10.1016/S0006-8993(97)00456-3