Genômica Nutricional nas Doenças Crônicas Não- Transmissiveis

Carga Horária: 30     Créditos: 2

Inicio: 15/08/2018 a 17/10/2018

Horário: Quarta-feira das 08h30 às12h

Local: dias 17 e 22/08 e 17/10/218-  sala de aula (21603) no 6º andar do Centro de Pesquisa Clinica (CPC). Demais datas, sala de videconferência do CPC.

Professores: Thais Steemburgo e Helen Hermana Hermsdorff .

Ementa: fundamentos da genômica nutricional. Interação gene-nutriente na obesidade e diabetes. Interação gene-nutriente nas doenças cardiovasculares (DCV). Interação gene-nutriente no câncer. Avanços e novas direções nas ômicas e bioinformação.

Conteúdo Programático:

  • Fundamentos da Gênomica Nutricional: histórico, expressão gênica, nutrigenética, nutrigenômica e epigenética.
  • Interação gene-nutriente na obesidade e diabetes: polimorfismos e obesidade, polimorfismos e diabetes. Interação gene-nutriente no ganho e na perda de peso. Interação gene e componentes da dieta no diabetes.
  • Interação gene-nutriente nas DCV: polimorfismos e DCV. Interação gene e ácidos graxos nas DCV.
  • Interação gene-nutriente no câncer: polimorfismos e câncer. Interação gene e compostos bioativos no câncer.
  • Avanços e novas direções nas ômicas e bioinformação.

Metodologia de trabalho: aulas expositivas dialogadas e em videoconferência (Profa. Helen Hermana Hermsdorff - Universidade Federal Viçosa), seminários e discussão de artigos científicos.

Avaliação: participação nas atividades (20%) e apresentação de seminários (80%).

Bibliografia:

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  • Ribeiro PVM, Silva A, Almeida AP, Hermsdorff HH, Alfenas RC. Effect of chronic consumption of pistachios (Pistacia vera L.) on glucose metabolism in pre-diabetics and type 2 diabetics: A systematic review. Crit Rev Food Sci Nutr. 1-9. doi: 10.1080/10408398.2017.1392290, 2017.
  • Rocha DM, Bressan J, Hermsdorff HH. The role of dietary fatty acid intake in Inflammatory gene expression: a critical review. Sao Paulo Med J. 135(2):157-168, 2017.
  • Rocha DM, Caldas AP, Oliveira LL, Bressan J, Hermsdorff HH. Saturated fatty acids trigger TLR4-mediated inflammatory response. Atherosclerosis.244:211-5, 2016.
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  • Steemburgo et al. The rs7204609 Polymorphism in the Fat Mass and Obesity-Associated gene is positively associated with central obesity and microalbuminuria in patients with type 2 diabetes from Southern Brazil. J Ren Nutr 22 (2): 228-36, 2012.
  • Steemburgo et al. The rs9939609 Polymorphism in the FTO Gene Is Associated with Fat and Fiber Intakes in Patients with Type 2 Diabetes. J Nutrigenet Nutrigenomics 2013;6:97–106, 2013.
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