Calendário de Defesas e Seminários

Data: Quarta-feira, 19 de Junho de 2019 (12:00 - 23:59)



Epidemiologic profile of children born to mothers infected by zika virus in Tangara da Serra, MT 

Orientadora: Dra.  Lavínia Schüler-Faccini

Avaliador: Dr. Rafael Bisso Machado



The relation between Zika virus (ZIKV) and microcephaly, ocular and auditory abnormalities in newborns is well established. The teratogenic effect may occur during the three trimesters of gestation. However, most of the children born from mothers exposed to the ZIKV during pregnancy are non-microcephalic at birth, but may present neurological impairments including delayed neuropsychomotor development and microcephaly after a few months of life. However, no population-based study was published until now. Center-West of Brazil was the second region to be affected by ZIKV outbreak by the end of 2015 to the beginning of 2016. Therefore we selected a medium-sized city in Mato Grosso (Tangará da Serra – TS), to characterize the prevalence and epidemiological profile of children born with congenital anomalies on a period of 11 years with special focus on the year 2016. This year all livebirths were evaluated according maternal exposure to ZIKV during pregnancy. Head circumference (HC) was classified according Intergrowth21st charts and all children born with HC less than -2Zscores from the mean were classified as microcephalic. GPS was used for geographic location of residence of mothers during pregnancy. The project was approved by local ethics committees and registered in Plataforma Brazil under the number CAAE: 56176616.2.1001.5327. We observed a peak of congenital malformations in year 2016 compared to the ten previous years (2006-2015), mainly explained by microcephaly. In 2016, 1441 newborns from mothers living in TS were registered. One hundred and six mothers were considered exposed to ZIKV (7,3%). The prevalence of children with microcephaly due to ZIKV was 34/10.000, ten times more than that observed in the same period in Rio Grande do Sul (3,4/10.000). The geographical analysis is under way and will allow detecting possible clusters of infection in TS. Our observation of 5/106 (4.7%) children born with microcephaly is somewhat lower than other estimates (10%). This is perhaps due to the fact that ours is a population studies while the available published studies are mostly based in case series which usually overestimate risks.

Funding: Ministry of Health, CNPq, CAPES, FAPERGS

Local  Anfiteatro do Departamento de Genética, Prédio 43312, Campus do Vale/UFRGS
por Tamara Moch