{"id":70432,"date":"2023-09-14T07:30:00","date_gmt":"2023-09-14T10:30:00","guid":{"rendered":"https:\/\/www.ufrgs.br\/jornal\/?p=70432"},"modified":"2023-12-06T11:04:39","modified_gmt":"2023-12-06T14:04:39","slug":"study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/","title":{"rendered":"Study indicates that anti-inflammatory treatments may retard the progression of Alzheimer\u2019s disease"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\"><strong>Neurosciences | Results indicate that a variant of the APOE gene affects the progression of the neurodegenerative disease through inflammation of the brain<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\" style=\"font-size:10px\"><em>*By Oberdan Rodrigo Schumann<br>*First published May 11, 2023<br>*Photo: Jo\u00e3o Pedro Ferrari Souza\/Personal Archive<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The causes of the onset and progression of Alzheimer\u2019s disease (AD), which accounts for approximately 70% of dementia cases worldwide, are still little understood by medicine. Some of its risk factors are known: habits such as tobacco smoking, diseases such as diabetes, and genetic factors are examples in this regard. A few measures that help prevent it are also known, such as physical activity and mental exercise. The current treatments for Alzheimer\u2019s patients are symptomatic, i.e. they do not stop or even retard the progression of the disease.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The research study <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.ade1474\">\u201c<em>APOE<\/em>\u03b54 associates with microglial activation independently of A\u03b2 plaques and tau tangles\u201d<\/a>, conducted by Jo\u00e3o Pedro Ferrari Souza, a doctoral student in&nbsp;<a href=\"https:\/\/www.ufrgs.br\/ppgbioq\/en\/home-page\/\">UFRGS\u2019 Graduate Research Program in Biological Sciences: Biochemistry (PPGBIOQ)<\/a>, addresses the main genetic risk factor for Alzheimer\u2019s disease: the e4 variant of the <em>APOE <\/em>gene, which encodes polyprotein E. Its results register the first clinical evidence of the influence of this gene on the progression of Alzheimer\u2019s through inflammation of the brain.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cOur results suggest that treatments seeking to reduce inflammation of the brain can potentially help contain the progression of Alzheimer\u2019s disease, especially in patients who carry the <em>APOE4<\/em> gene,\u201d Souza explains. The study resulted in an&nbsp;<a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.ade1474\">article published in&nbsp;<em>Science Advances<\/em><\/a><em>&nbsp;<\/em>in early April.&nbsp;\u201cThis article guarantees that the study will be read by important researchers and that it will be a basis for future research on the disease,\u201d he emphasizes.<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>Glial cells and the <\/strong><strong><em>APOE<\/em><\/strong><strong> gene<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">In PPGBIOQ, Souza is supervised by professor Eduardo Zimmer, of UFRGS\u2019 Department of Pharmacology. \u201cProfessor Zimmer has been long researching a specific type of cell, glial cells. And my research project was always aimed at a deeper understanding about the influence of such glial cells on Alzheimer\u2019s disease,\u201d he adds.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Glial cells are the main producers of polyprotein E in the human brain. This protein is expressed by the <em>APOE<\/em> gene, which has three variants:&nbsp;<em>APOE3<\/em>, carried by most of the world\u2019s population; <em>APOE2<\/em>, which has a protective effect against Alzheimer\u2019s disease; and lastly, <em>APOE4<\/em>, considered the greatest risk factor for the development of the disease.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cEven if we know this, we don\u2019t understand very well the mechanisms by which <em>APOE4<\/em> increases the risk for Alzheimer\u2019s disease. Full comprehension of such mechanisms is very important because of two reasons: first, we need to understand the natural progression of the disease, and secondly, we need to develop treatments,\u201d Souza stresses.<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>Neuroinflammation and its relationship with Alzheimer\u2019s disease<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">Alzheimer\u2019s disease occurs mainly when two types of proteins \u2013 amyloids and tau proteins \u2013 build up in the brain and start to harm it, causing neuronal cell death and a series of illnesses, such as atrophy. These aggressions activate a type of glial cell called microglia. In turn, these defense cells cause the brain to enter a state of neuroinflammation, which contributes directly to the progression and acceleration of the disease.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Although studies using animal subjects have been carried out, Souza\u2019s research shows the first evidence in humans supporting that <em>APOE4<\/em> causes AD progression and neuroinflammation.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><em>\u201cThere is still a lot to be studied and validated, but the research results so far obtained suggest that anti-inflammatory treatments can possibly reduce the progression of AD, especially in patients that have this e4 variant. Apparently, this needs to be done in the earliest moments of the disease, when the pathological process starts occurring in the brain\u201d<\/em><\/p>\n<cite>Jo\u00e3o Pedro Ferrari Souza<\/cite><\/blockquote>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>Next steps&nbsp;<\/strong><\/h5>\n\n\n\n<p class=\"wp-block-paragraph\">Souza carried out his research during a sandwich doctorate at the University of Pittsburgh, in the United States. There, he studied a more clinical part of his advisor\u2019s work to understand how glial cells affect Alzheimer\u2019s disease in humans.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The partnership between the University of Pittsburgh and Canada\u2019s McGill University was crucial to the activities of the research. \u201cMcGill has a great patient cohort that allows several biological markers for Alzheimer\u2019s disease to be followed up,\u201d Souza explains.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To Souza, the next steps involve carrying out research on the reduction of inflammation of the brain and understanding its consequences for the Alzheimer patient. Furthermore, he points out that studies on <em>APOE<\/em> are far from over. \u201cIt can be said that the variant has a manifold contribution. Our line of research seeks to understand a bit more the many contributions of this gene to the disease,\u201d he concludes.<\/p>\n\n\n\n<p class=\"has-accent-background-color has-background wp-block-paragraph\">Translated into English by\u00a0<strong><em>Daniel Senna Irgang<\/em><\/strong>, undergraduate student enrolled in the course \u201cSupervised Translation Training II (English)\u201d of the Undergraduate Program in Language and Literature, under the supervision and translation revision of Professor Elizamari R. Becker (P.h.D.).<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-dots\"\/>\n","protected":false},"excerpt":{"rendered":"<p>Neurosciences | Results indicate that a variant of the APOE gene affects the progression of the neurodegenerative disease through inflammation of the brain<span class=\"more-link\"><a href=\"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/\">Leia mais<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":63897,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_themeisle_gutenberg_block_has_review":false,"page_builder":"","footnotes":"","_ppma_block_editor_authors":""},"categories":[4495],"tags":[],"ppma_author":[5133],"class_list":["entry","author-oberdan-rodrigo-schumann","has-excerpt","post-70432","post","type-post","status-publish","format-standard","has-post-thumbnail","category-in-english"],"pp_statuses_selecting_workflow":false,"pp_workflow_action":"current","pp_status_selection":"publish","yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Study indicates that anti-inflammatory treatments may retard the progression of Alzheimer\u2019s disease - Jornal da Universidade<\/title>\n<meta name=\"description\" content=\"Neurosciences | Results indicate that a variant of the APOE gene affects the progression of the neurodegenerative disease through inflammation of the brain\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study indicates that anti-inflammatory treatments may retard the progression of Alzheimer\u2019s disease - Jornal da Universidade\" \/>\n<meta property=\"og:description\" content=\"Neurosciences | Results indicate that a variant of the APOE gene affects the progression of the neurodegenerative disease through inflammation of the brain\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Jornal da Universidade\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/jornaldauniversidadeufrgs\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-14T10:30:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-12-06T14:04:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ufrgs.br\/jornal\/wp-content\/uploads\/2023\/05\/Foto_JP_UFRGS-scaled-compress.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Oberdan Rodrigo Schumann\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@jornaldaufrgs\" \/>\n<meta name=\"twitter:site\" content=\"@jornaldaufrgs\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\\\/\"},\"author\":{\"name\":\"Jornal da Universidade\",\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/#\\\/schema\\\/person\\\/6a4a28aca6862d44478244aebd5cd3d6\"},\"headline\":\"Study indicates that anti-inflammatory treatments may retard the progression of Alzheimer\u2019s disease\",\"datePublished\":\"2023-09-14T10:30:00+00:00\",\"dateModified\":\"2023-12-06T14:04:39+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\\\/\"},\"wordCount\":835,\"publisher\":{\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/wp-content\\\/uploads\\\/2023\\\/05\\\/Foto_JP_UFRGS-scaled-compress.jpg\",\"articleSection\":[\"In English\"],\"inLanguage\":\"pt-BR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\\\/\",\"url\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\\\/\",\"name\":\"Study indicates that anti-inflammatory treatments may retard the progression of Alzheimer\u2019s disease - Jornal da Universidade\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/wp-content\\\/uploads\\\/2023\\\/05\\\/Foto_JP_UFRGS-scaled-compress.jpg\",\"datePublished\":\"2023-09-14T10:30:00+00:00\",\"dateModified\":\"2023-12-06T14:04:39+00:00\",\"description\":\"Neurosciences | Results indicate that a variant of the APOE gene affects the progression of the neurodegenerative disease through inflammation of the brain\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\\\/#breadcrumb\"},\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/wp-content\\\/uploads\\\/2023\\\/05\\\/Foto_JP_UFRGS-scaled-compress.jpg\",\"contentUrl\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/wp-content\\\/uploads\\\/2023\\\/05\\\/Foto_JP_UFRGS-scaled-compress.jpg\",\"width\":1500,\"height\":1000},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"In\u00edcio\",\"item\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Study indicates that anti-inflammatory treatments may retard the progression of Alzheimer\u2019s disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/#website\",\"url\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/\",\"name\":\"Jornal da Universidade | UFRGS\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/#organization\"},\"alternateName\":\"JU | UFRGS\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pt-BR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/#organization\",\"name\":\"Universidade Federal do Rio Grande do Sul\",\"alternateName\":\"UFRGS\",\"url\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/wp-content\\\/uploads\\\/2020\\\/07\\\/LOGOS-UFRGS-PRETO_VERMELHO-e1586884311936.jpg\",\"contentUrl\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/wp-content\\\/uploads\\\/2020\\\/07\\\/LOGOS-UFRGS-PRETO_VERMELHO-e1586884311936.jpg\",\"width\":83,\"height\":64,\"caption\":\"Universidade Federal do Rio Grande do Sul\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/jornaldauniversidadeufrgs\",\"https:\\\/\\\/x.com\\\/jornaldaufrgs\",\"https:\\\/\\\/www.instagram.com\\\/ufrgs.jornal\\\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.ufrgs.br\\\/jornal\\\/#\\\/schema\\\/person\\\/6a4a28aca6862d44478244aebd5cd3d6\",\"name\":\"Jornal da Universidade\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Study indicates that anti-inflammatory treatments may retard the progression of Alzheimer\u2019s disease - Jornal da Universidade","description":"Neurosciences | Results indicate that a variant of the APOE gene affects the progression of the neurodegenerative disease through inflammation of the brain","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/","og_locale":"pt_BR","og_type":"article","og_title":"Study indicates that anti-inflammatory treatments may retard the progression of Alzheimer\u2019s disease - Jornal da Universidade","og_description":"Neurosciences | Results indicate that a variant of the APOE gene affects the progression of the neurodegenerative disease through inflammation of the brain","og_url":"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/","og_site_name":"Jornal da Universidade","article_publisher":"https:\/\/www.facebook.com\/jornaldauniversidadeufrgs","article_published_time":"2023-09-14T10:30:00+00:00","article_modified_time":"2023-12-06T14:04:39+00:00","og_image":[{"width":1500,"height":1000,"url":"https:\/\/www.ufrgs.br\/jornal\/wp-content\/uploads\/2023\/05\/Foto_JP_UFRGS-scaled-compress.jpg","type":"image\/jpeg"}],"author":"Oberdan Rodrigo Schumann","twitter_card":"summary_large_image","twitter_creator":"@jornaldaufrgs","twitter_site":"@jornaldaufrgs","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/#article","isPartOf":{"@id":"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/"},"author":{"name":"Jornal da Universidade","@id":"https:\/\/www.ufrgs.br\/jornal\/#\/schema\/person\/6a4a28aca6862d44478244aebd5cd3d6"},"headline":"Study indicates that anti-inflammatory treatments may retard the progression of Alzheimer\u2019s disease","datePublished":"2023-09-14T10:30:00+00:00","dateModified":"2023-12-06T14:04:39+00:00","mainEntityOfPage":{"@id":"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/"},"wordCount":835,"publisher":{"@id":"https:\/\/www.ufrgs.br\/jornal\/#organization"},"image":{"@id":"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/www.ufrgs.br\/jornal\/wp-content\/uploads\/2023\/05\/Foto_JP_UFRGS-scaled-compress.jpg","articleSection":["In English"],"inLanguage":"pt-BR"},{"@type":"WebPage","@id":"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/","url":"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/","name":"Study indicates that anti-inflammatory treatments may retard the progression of Alzheimer\u2019s disease - Jornal da Universidade","isPartOf":{"@id":"https:\/\/www.ufrgs.br\/jornal\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/#primaryimage"},"image":{"@id":"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/www.ufrgs.br\/jornal\/wp-content\/uploads\/2023\/05\/Foto_JP_UFRGS-scaled-compress.jpg","datePublished":"2023-09-14T10:30:00+00:00","dateModified":"2023-12-06T14:04:39+00:00","description":"Neurosciences | Results indicate that a variant of the APOE gene affects the progression of the neurodegenerative disease through inflammation of the brain","breadcrumb":{"@id":"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/#breadcrumb"},"inLanguage":"pt-BR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/"]}]},{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/#primaryimage","url":"https:\/\/www.ufrgs.br\/jornal\/wp-content\/uploads\/2023\/05\/Foto_JP_UFRGS-scaled-compress.jpg","contentUrl":"https:\/\/www.ufrgs.br\/jornal\/wp-content\/uploads\/2023\/05\/Foto_JP_UFRGS-scaled-compress.jpg","width":1500,"height":1000},{"@type":"BreadcrumbList","@id":"https:\/\/www.ufrgs.br\/jornal\/study-indicates-that-anti-inflammatory-treatments-may-retard-the-progression-of-alzheimers-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"In\u00edcio","item":"https:\/\/www.ufrgs.br\/jornal\/"},{"@type":"ListItem","position":2,"name":"Study indicates that anti-inflammatory treatments may retard the progression of Alzheimer\u2019s disease"}]},{"@type":"WebSite","@id":"https:\/\/www.ufrgs.br\/jornal\/#website","url":"https:\/\/www.ufrgs.br\/jornal\/","name":"Jornal da Universidade | UFRGS","description":"","publisher":{"@id":"https:\/\/www.ufrgs.br\/jornal\/#organization"},"alternateName":"JU | UFRGS","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.ufrgs.br\/jornal\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"pt-BR"},{"@type":"Organization","@id":"https:\/\/www.ufrgs.br\/jornal\/#organization","name":"Universidade Federal do Rio Grande do Sul","alternateName":"UFRGS","url":"https:\/\/www.ufrgs.br\/jornal\/","logo":{"@type":"ImageObject","inLanguage":"pt-BR","@id":"https:\/\/www.ufrgs.br\/jornal\/#\/schema\/logo\/image\/","url":"https:\/\/www.ufrgs.br\/jornal\/wp-content\/uploads\/2020\/07\/LOGOS-UFRGS-PRETO_VERMELHO-e1586884311936.jpg","contentUrl":"https:\/\/www.ufrgs.br\/jornal\/wp-content\/uploads\/2020\/07\/LOGOS-UFRGS-PRETO_VERMELHO-e1586884311936.jpg","width":83,"height":64,"caption":"Universidade Federal do Rio Grande do Sul"},"image":{"@id":"https:\/\/www.ufrgs.br\/jornal\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/jornaldauniversidadeufrgs","https:\/\/x.com\/jornaldaufrgs","https:\/\/www.instagram.com\/ufrgs.jornal\/"]},{"@type":"Person","@id":"https:\/\/www.ufrgs.br\/jornal\/#\/schema\/person\/6a4a28aca6862d44478244aebd5cd3d6","name":"Jornal da Universidade"}]}},"authors":[{"term_id":5133,"user_id":0,"is_guest":1,"slug":"oberdan-rodrigo-schumann","display_name":"Oberdan Rodrigo Schumann","avatar_url":"https:\/\/secure.gravatar.com\/avatar\/?s=96&d=mm&r=g","author_category":"","user_url":"","last_name":"Schumann","first_name":"Oberdan Rodrigo","job_title":"","description":"Estudante de Jornalismo na UFRGS"}],"_links":{"self":[{"href":"https:\/\/www.ufrgs.br\/jornal\/wp-json\/wp\/v2\/posts\/70432","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ufrgs.br\/jornal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ufrgs.br\/jornal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ufrgs.br\/jornal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ufrgs.br\/jornal\/wp-json\/wp\/v2\/comments?post=70432"}],"version-history":[{"count":0,"href":"https:\/\/www.ufrgs.br\/jornal\/wp-json\/wp\/v2\/posts\/70432\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ufrgs.br\/jornal\/wp-json\/wp\/v2\/media\/63897"}],"wp:attachment":[{"href":"https:\/\/www.ufrgs.br\/jornal\/wp-json\/wp\/v2\/media?parent=70432"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ufrgs.br\/jornal\/wp-json\/wp\/v2\/categories?post=70432"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ufrgs.br\/jornal\/wp-json\/wp\/v2\/tags?post=70432"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.ufrgs.br\/jornal\/wp-json\/wp\/v2\/ppma_author?post=70432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}