{"id":17020,"date":"2025-10-08T14:31:29","date_gmt":"2025-10-08T17:31:29","guid":{"rendered":"https:\/\/www.ufrgs.br\/ppgbm\/?p=17020"},"modified":"2025-10-08T14:31:29","modified_gmt":"2025-10-08T17:31:29","slug":"13-10-seminario-de-qualificaca0-nitza-fereira-muniz","status":"publish","type":"post","link":"https:\/\/www.ufrgs.br\/ppgbm\/13-10-seminario-de-qualificaca0-nitza-fereira-muniz\/","title":{"rendered":"13\/10 – SEMIN\u00c1RIO DE QUALIFICA\u00c7\u00c30 – NITZA FEREIRA MUNIZ"},"content":{"rendered":"

SEMIN\u00c1RIO DE QUALIFICA\u00c7\u00c3O (Doutorado)<\/strong><\/p>\n

 <\/p>\n

NITZA FERREIRA MUNIZ<\/strong><\/p>\n

Vigil\u00e2ncia e aten\u00e7\u00e3o em anomalias cong\u00eanitas na regi\u00e3o noroeste do Paran\u00e1 (<\/strong>Surveillance of congenital anomalies in the northwestern region of Paran\u00e1 State, Brazil)<\/strong><\/p>\n

Orientadora: Dra. Lav\u00ednia Sch\u00fcler Faccini<\/p>\n

Banca examinadora: Dra. Maria Teresa Vieira Sanseverino e Dr. Claiton Henrique Dotto Bau<\/p>\n

13 de outubro de 2025 (segunda-feira)<\/p>\n

10h30min<\/strong><\/p>\n

Presencial:\u00a0<\/strong>Anfiteatro do\u00a0Departamento\u00a0de\u00a0Gen\u00e9tica da UFRGS (Campus do Vale, pr\u00e9dio 43312)<\/p>\n

 <\/p>\n

Resumo:<\/strong><\/p>\n

As anomalias cong\u00eanitas (AC) constituem uma das principais causas de morbimortalidade infantil, sendo respons\u00e1veis por cerca de 240 mil \u00f3bitos de rec\u00e9m-nascidos por ano em todo o mundo. No Brasil, figuram como a segunda principal causa de mortalidade infantil. O Sistema de Informa\u00e7\u00e3o sobre Nascidos Vivos (Sinasc) \u00e9 a principal fonte de dados para o registro dessas condi\u00e7\u00f5es ao nascer, entretanto, apresenta limita\u00e7\u00f5es relacionadas a falhas nos registros. Nesse sentido, na regi\u00e3o noroeste do Paran\u00e1 observam-se diversos casos de nascidos vivos (NV) registrados com AC n\u00e3o classificadas ou sem registro, mas com AC identificadas como causa do \u00f3bito, o que evidencia fragilidades na vigil\u00e2ncia dessas condi\u00e7\u00f5es. Dessa forma, o presente estudo tem como objetivo avaliar a preval\u00eancia e os padr\u00f5es espaciais das AC na regi\u00e3o noroeste do Paran\u00e1, a partir dos registros do Sinasc no per\u00edodo de 2010 a 2024 (an\u00e1lise retrospectiva) e de 2025 a 2027 (vigil\u00e2ncia prospectiva). O projeto foi aprovado pelo Comit\u00ea de \u00c9tica em Pesquisa do Hospital de Cl\u00ednicas de Porto Alegre (HCPA) e da Universidade Estadual de Maring\u00e1 (UEM). Trata-se de um estudo observacional dividido em duas etapas. A fase retrospectiva analisar\u00e1 dados secund\u00e1rios do Sinasc e do Sistema de Informa\u00e7\u00f5es sobre Mortalidade (SIM), enquanto a etapa prospectiva realizar\u00e1 vigil\u00e2ncia ativa em maternidades selecionadas, com aplica\u00e7\u00e3o de question\u00e1rio \u00e0s m\u00e3es, coleta de fatores de risco e registro fotogr\u00e1fico das anomalias mediante consentimento. Ser\u00e3o priorizadas AC de relev\u00e2ncia cl\u00ednica e epidemiol\u00f3gica, conforme recomenda\u00e7\u00f5es do minist\u00e9rio da Sa\u00fade. As an\u00e1lises incluir\u00e3o estimativas de preval\u00eancia, detec\u00e7\u00e3o de varia\u00e7\u00f5es temporais, georreferenciamento dos casos e linkage das bases Sinasc\u2013SIM. O aplicativo Global Birth Defects (GBDDC) ser\u00e1 empregado como ferramenta de apoio \u00e0 coleta de dados e ao treinamento de profissionais. Nesse contexto, a fase retrospectiva j\u00e1 foi iniciada, tendo sido avaliado o impacto das AC na mortalidade infantil no per\u00edodo de 2010 a 2019 em uma regional de sa\u00fade da regi\u00e3o noroeste, por meio da vincula\u00e7\u00e3o entre os dados de nascimento e de \u00f3bito. Ap\u00f3s o linkage Sinasc\u2013SIM, as cardiopatias cong\u00eanitas, inicialmente na s\u00e9tima posi\u00e7\u00e3o, passaram \u00e0 segunda entre as AC mais prevalentes. A taxa de mortalidade infantil por AC na regi\u00e3o (30,7\/10.000 NV) superou a m\u00e9dia nacional (28,0\/10.000 NV), evidenciando a import\u00e2ncia da vincula\u00e7\u00e3o de dados para fortalecer a vigil\u00e2ncia epidemiol\u00f3gica dessas condi\u00e7\u00f5es. Espera-se, assim, estabelecer uma linha de base regional para AC priorit\u00e1rias, aprimorar a qualidade dos registros e a detec\u00e7\u00e3o precoce, capacitar as equipes de sa\u00fade e identificar padr\u00f5es geogr\u00e1ficos e fatores de risco, contribuindo para a redu\u00e7\u00e3o da mortalidade infantil por essas condi\u00e7\u00f5es.<\/p>\n

 <\/p>\n

Abstract:<\/strong><\/p>\n

Congenital anomalies (CA) are among the leading causes of infant morbidity and mortality, accounting for approximately 240,000 newborn deaths worldwide each year. In Brazil, they represent the second leading cause of infant mortality. The Live Birth Information System (Sinasc) is the main national database for recording these conditions at birth; however, it presents limitations related to underreporting and incomplete data. In the northwestern region of Paran\u00e1, numerous live births (LB) are recorded with unclassified or missing CA data, while congenital anomalies are identified as causes of death, revealing weaknesses in surveillance and reporting systems. Accordingly, this study aims to assess the prevalence and spatial patterns of CA in the northwestern region of Paran\u00e1, based on Sinasc records from 2010 to 2024 (retrospective analysis) and from 2025 to 2027 (prospective surveillance). The project was approved by the Research Ethics Committees of the Hospital de Cl\u00ednicas de Porto Alegre (HCPA) and the State University of Maring\u00e1 (UEM). This is an observational study conducted in two phases. The retrospective phase will analyze secondary data from Sinasc and the Mortality Information System (SIM), while the prospective phase will implement active surveillance in selected maternity hospitals through maternal questionnaires, collection of risk factor data, and photographic documentation of anomalies with informed consent. Clinically and epidemiologically relevant CA will be prioritized, following the recommendations of the Brazilian Ministry of Health. Analyses will include prevalence estimates, detection of temporal variations, spatial mapping of cases, and probabilistic linkage between Sinasc and SIM databases. The Global Birth Defects (GBDDC) application will be used as a tool to support data collection and professional training. In this context, the retrospective phase has already begun, including an evaluation of the impact of CA on infant mortality between 2010 and 2019 in one health region of northwestern Paran\u00e1 through data linkage between birth and death records. After linkage, congenital heart defects, initially ranked seventh, became the second most prevalent CA. The infant mortality rate due to CA in the region (30.7\/10,000 LB) exceeded the national average (28.0\/10,000 LB), underscoring the importance of multiple sources to strengthen epidemiological surveillance. It is expected that this project will establish a regional baseline for priority CAs, improve data quality and early detection, strengthen the capacity of health teams, and identify spatial and environmental risk patterns, thereby contributing to the reduction of infant mortality due to congenital anomalies.<\/p>\n","protected":false},"excerpt":{"rendered":"

SEMIN\u00c1RIO DE QUALIFICA\u00c7\u00c3O (Doutorado)   NITZA FERREIRA MUNIZ Vigil\u00e2ncia e aten\u00e7\u00e3o em anomalias cong\u00eanitas na regi\u00e3o noroeste do Paran\u00e1 (Surveillance of congenital anomalies in the northwestern region of Paran\u00e1 State, […]<\/p>\n","protected":false},"author":3,"featured_media":17021,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-17020","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-seminarios-e-defesas"],"_links":{"self":[{"href":"https:\/\/www.ufrgs.br\/ppgbm\/wp-json\/wp\/v2\/posts\/17020","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ufrgs.br\/ppgbm\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ufrgs.br\/ppgbm\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ufrgs.br\/ppgbm\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ufrgs.br\/ppgbm\/wp-json\/wp\/v2\/comments?post=17020"}],"version-history":[{"count":1,"href":"https:\/\/www.ufrgs.br\/ppgbm\/wp-json\/wp\/v2\/posts\/17020\/revisions"}],"predecessor-version":[{"id":17022,"href":"https:\/\/www.ufrgs.br\/ppgbm\/wp-json\/wp\/v2\/posts\/17020\/revisions\/17022"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ufrgs.br\/ppgbm\/wp-json\/wp\/v2\/media\/17021"}],"wp:attachment":[{"href":"https:\/\/www.ufrgs.br\/ppgbm\/wp-json\/wp\/v2\/media?parent=17020"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ufrgs.br\/ppgbm\/wp-json\/wp\/v2\/categories?post=17020"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ufrgs.br\/ppgbm\/wp-json\/wp\/v2\/tags?post=17020"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}