The synthesis of new coumarins proposed by LaSOM generated a series of new structures that were evaluated against Trypanosama cruzi's parasite, responsible for Chagas disease. The biological tests were carried out in partnership with LATOX, which evaluated the molecules in the alternative in vivo model Caenorhabditis elegans. In addition, based on the results, a quantitative structure-activity relationship (QSAR) was prepared based on methods provided by chemoinformatics. Check out the article here.