Leishmaniasis is a disease caused by protozoa of the genus Leishmania , affecting millions of people around the world and is still neglected. The disease can be present from asymptomatic forms to systemic complications! Pharmacological treatments available still have significant disadvantages, making it difficult to treat infected people. So, a series of new molecules have been tested as alternatives to combat the protozoan, among them, the coumarin class. This review aims to present coumarins with prominence in this application in addition to proposing a structure-activity relationship (SAR), looking for patterns to guide new experiments. You can find the link to access the article here . Nice reading!