A signaling pathway to the cytoskeleton. Axon guidance receptors potentially bind the Nck adaptor, through both SH2-and SH3-mediated interactions. The second SH3 domain of Nck recruits the Pak protein-serine/threonine kinase to the membrane. Pak kinase activity is induced by binding of GTP-Cdc42 to a CRIB motif. Pak can also generate activated Cdc42 through the associated PIX GEF. (Pro = proline-rich motif).
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