A; Activation of Rsk1 requires phosphorylation by both PDK1 and ERK MAPK. Thus the PI3K and Ras pathways synergize to stimulate the Rsk1 protein-serine/threonine kinase.
B; Signaling through the IFNg receptor/Stat3 pathway induces the expression of the inhibitory Smad7, which blocks the activity of the TGFb receptor. Thus one cytokine pathway inhibits the activation of a distinct pathway.
C; Both the Wnt receptor (DFz2) and the related Frizzled signal through the multi-domain protein Dishevelled. Wnt signaling involves the DIX and PDZ domains of Dishevelled, which activate the b-catenin pathway. Frizzled signals through the C-terminal DEP domain to activate the JNK MAPK pathway.
Copyright © 2001-2014 Daniele Focosi.
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