Mena interacts with receptors, focal adhesion components and bacterial
pathogens through its EVH1 domain, and has multiple motifs that potentially
couple to the actin cytoskeleton. UNC-73/Trio has an N-terminal domain
related to yeast Sec 14, multiple spectrin repeats, and two DH-PH domains
that activate Rac and Rho respectively. The signaling pathways that lie
upstream of UNC-73/Trio are not well established.
Copyright © 2001-2014 Daniele Focosi.
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