MAIN G12PCRs (Ga12 and Ga13)

Click here for their STP.
Common biological outputs :

GPCR name
ligand(s)
expressed on ...
agonists
antagonists
TP (also GqPCR) TxA2
PGH2
platelets
smooth muscle cells
U44619 / U46619 GR32191 
BM-531 (N-tert-butyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea) 
BM-567 (N-pentyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea) 
sulotroban 
ridrogrel
TxA1R TxA1
AT1a (it can homodimerize) angiotensin II cardiovascular cells 
  • juxtaglomerular cells JGC) for short-loop negative feedback mechanism of renin incretion
  • vascular smooth muscle cells of precapillary arterioles and postcapillary venules
-artans 
  • bithienylmethylacrylic acid derivative
    • eprosartan (Teveten®)
  • biphenylmethyl derivatives
    • candesartan cilexetil (Atacand®)
    • irbesartan (Avapro®)
    • losartan (Cozaar®)
    • telmisartan (Micardis®)
    • valsartan (Diovan®)
(Ga13) LPA
(Ga12) ET-1
ET-2
ET-3

Web resources :


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