Click here for their STP.
Common biological outputs :

• opening of Ca²⁺ HVA N channels and closure of K⁺_M channels =>
• depolarization or excitatory postsynaptic potential (EPSP)
• exocytosis
• contraction of smooth and skeletal muscles

GPCR name	ligand(s)	expressed on ...	agonists	antagonists
TP (also GqPCR)	TxA2 PGH2	platelets smooth muscle cells	U44619 / U46619	GR32191  BM-531 (N-tert-butyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea)  BM-567 (N-pentyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea)  sulotroban  ridrogrel
TxA1R	TxA1
AT1a (it can homodimerize)	angiotensin II	cardiovascular cells  juxtaglomerular cells JGC) for short-loop negative feedback mechanism of renin incretion vascular smooth muscle cells of precapillary arterioles and postcapillary venules		-artans  bithienylmethylacrylic acid derivative eprosartan (Teveten®) biphenylmethyl derivatives candesartan cilexetil (Atacand®) irbesartan (Avapro®) losartan (Cozaar®) telmisartan (Micardis®) valsartan (Diovan®)
(Ga13)	LPA
(Ga12)	ET-1 ET-2 ET-3

Web resources :

• Ga₁₂ pathway at STKE [free registration required !]
• Ga₁₃ pathway at STKE [free registration required !]

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