LabSinal

2026

OPEN

Journal of Molecular Medicine

Temozolomide increases the generation of cell heterogeneity in ERK activity in glioma cells

Begnini, K; Marcolim, JC; Pereira, L; Souza, L; Kraemer-Mattos, F; Torgo, D; Machemer, C; Goulart, G; Silva, A; Santos, JA; Lenz, G.

DOI: 10.1007/s00109-026-02644-2

ACCESS

2025

OPEN

BMC Methods

CloVarS: a simulation of single-cell clonal variability

Faccioni, JL; Kraemer-Mattos, F; Begnini, K; Buss, J; Torgo, D; Mattos, C; Cassel, C; Seidel, S; Brunnet, LG; Oliveira, M; Lenz. G.

DOI: 10.1186/s44330-025-00033-8

ACCESS

2024

OPEN

BBA - Molecular Basis of Disease

Heterogeneity generating capacity in tumorigenesis and cancer therapeutics.

Guido Lenz

DOI: 10.1016/j.bbadis.2024.167226

ACCESS

2024

OPEN

TCell Communication and Signaling

CD73 mitigates ZEB1 expression in papillary thyroid carcinoma

Vedovatto, S; Oliveira, FDP; Cherubini L; Beckenkamp], LR; Bertoni, APS; Wink, MR; Lenz, G.

DOI: 10.1186/s12964-024-01522-z

ACCESS

2024

OPEN

Translational Medicine Communications

Expression of key unfolded protein response genes predicts patient survival and an immunosuppressive microenvironment in glioblastoma.

Oliveira, FD; De Campos, RP; Pereira, LC; Meira, LB; Lenz, G.

DOI: 10.1186/s41231-024-00164-0

ACCESS

2024

OPEN

Journal of Cell Science

The contribution of asymmetric cell division to phenotypic heterogeneity in cancer.

Buss JH, Begnini KR, Lenz G.

DOI: 10.1242/jcs.261400

ACCESS

2023

OPEN

Experimental Cell Research

Mitochondrial response of glioma cell to temozolomide.

Lenz LS, Lemos DT, Buss JH, Pereira LC, Bueno M, Filippi-Chiela EC, Lenz G.

DOI: 10.1016/j.yexcr.2023.113825

ACCESS

2023

OPEN

Experimental Cell Research, v. 430, n.1, p. 113715

Asymmetric mitosis contributes to different migratory performance in sister cells.

Tamborindeguy MT, Lorenzatto PF, Lamers ML, Lenz G.

DOI: 10.1016/j.yexcr.2023.113715

ACCESS

2023

OPEN

Journal of Cell Science

The role of mitosis in generating fitness heterogeneity.

Buss JH, Lenz LS, Pereira LC, Torgo D, Marcolin J, Begnini KR, Lenz G.

DOI: 10.1242/jcs.260103

ACCESS

2022

OPEN

Seminars in Cancer Biology

The crossroads of adenosinergic pathway and epithelial-mesenchymal plasticity in cancer.

Iser IC, Vedovatto S, Oliveira FD, Beckenkamp LR, Lenz G, Wink MR.

DOI: 10.1016/j.semcancer.2022.06.012

ACCESS

2022

OPEN

Biochemical Society Transactions, v. 50, p. 513-527

Bioimaging approaches for quantification of individual cell behavior during cell fate decisions.

Begnini KR, Pereira LC, Faccioni JL, Lenz G, Filippi-Chiela, EC.

DOI: 10.1042/BST20210534

ACCESS

2021

OPEN

Cancer Research

The Origins of Phenotypic Heterogeneity in Cancer.

Lenz G, Onzi GR, Lenz LS, Buss JH, Santos JAF, Begnini KR.

DOI: 10.1158/0008-5472.CAN-21-1940

ACCESS

2021

OPEN

Cancer Research, v. 81, p. 1040-1051

Cancer Cell Fitness is Dynamic.

Lenz LS, Faccioni JL, Bracco PA, Santos JAF, et al.

DOI: 10.1158/0008-5472.CAN-20-2488

ACCESS

2021

OPEN

Oncotarget, v. 12, p. 1962-1965

The role of dynamic phenotypes in cancer.

Lenz LS and Lenz G.

DOI: 10.18632/oncotarget.28006

ACCESS

2021

OPEN

Purinergic Signalling, v. 18, p. 1

ENTPD5: identification of splicing variants and their impact on cancer survival.

de Campos RP, Wink MR, Lenz G.

DOI: 10.1007/s11302-021-09795-6

ACCESS

2019

OPEN

Biochemical and Biophysical Research Communications, v. 517, p. 324-329

Silencing of the transcription factors Oct4, Sox2, Klf4, c-Myc or Nanog has different effect on teratoma growth.

Villodre ES, Felipe KB, Oyama M, Oliveira F, da Costa Lopez PL, Solari C, Slevender G, Guberman A, Lenz G.

DOI: 10.1016/j.bbrc.2019.07.064

ACCESS

2019

OPEN

Experimental Cell Research, v. 382, p. 111456-111466

Dipyridamole impairs autophagic flux and exerts antiproliferative activity on prostate cancer cells.

Thome MP, Pereira LC, Onzi GR, Rohden F, Ilha M, Guma FT, Wink MR, Lenz G.

DOI: 0.1016/j.yexcr.2019.06.001

ACCESS

2019

OPEN

Cancer Research, v. 79(5), p. 1010-1013

esiCancer: Evolutionary in silico Cancer Simulator.

Minussi D.C., Henz B., Oliveira M.S., Filippi-Chiela E.C., Oliveira M.M., Lenz G.

DOI: 10.1158/0008-5472.CAN-17-3924.

ACCESS

2018

OPEN

OncoImmunology, v. 1, n. e1431083

Transcriptional characterization of immunological infiltrates and their relation with glioblastoma patients overall survival.

Pereira MB, Barros LRC, Bracco PA, Vigo A, Boroni M, Bonamigo MH, Lenz G.

DOI: 10.1080/2162402X.2018.1431083

ACCESS

2018

OPEN

Molecular Neurobiology, v. 55, p. 4185-4194

Low Dose of Doxorubicin Potentiates the Effect of Temozolomide in Glioblastoma Cells.

Villodre ES, Kipper FC, Silva AO, Da Costa Lopez PL, Lenz G.

DOI: 10.1007/s12035-017-0611-6

ACCESS

2017

OPEN

Oncotarget, v. 8, p. 69185-69197

Culture conditions defining glioblastoma cells behavior: what is the impact for novel discoveries?.

Ledur PF, Onzi GR, Zong H, Lenz G.

DOI: 10.18632/oncotarget.20193

ACCESS

2017

OPEN

Investigational New Drugs, v. 36, p. 323-331

Vinblastine and antihelmintic mebendazole potentiate temozolomide in resistant gliomas.

Kipper FC, Silva AO, Marc AL, Confortin G, Junqueira AV, Neto EP, Lenz G.

DOI: 10.1007/s10637-017-0503-7

ACCESS

2016

OPEN

Autophagy (Georgetown, TX), v. 12, p. 1-222

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, DJ et al

DOI: 10.1080/15548627.2015.1100356.

ACCESS

2016

OPEN

Molecular Pharmacology, v. 90, p. 371-384

Modulation of Autophagy by Calcium Signalosome in Human Disease.

Filippi-Chiela EC, Viegas MS, Thomé MP, Buffon A, Wink MR, Lenz G.

DOI: 10.1124/mol.116.105171

ACCESS

2016

OPEN

Experimental Cell Research, v. 348, p. 177-183

The regrowth kinetic of the surviving population is independent of acute and chronic responses to temozolomide in glioblastoma cell lines.

Silva AO, Dalsin E, Onzi GR, Filippi-Chiela EC, Lenz G.

DOI: 10.1016/j.yexcr.2016.09.014

ACCESS

2016

OPEN

Cancer Treatment Reviews, v. 51, p. 1-9

Roles of OCT4 in tumorigenesis, cancer therapy resistance and prognosis.

Villodre ES, Kipper FC, Pereira MB, Lenz G.

DOI: 10.1016/j.ctrv.2016.10.003

ACCESS

2016

OPEN

Tumor Biology, v. 37, p. 13743-13749

A guide for the analysis of long-term population growth in cancer.

Silva AO, Felipe KB, Villodre ES, Lopez PL, Lenz G.

DOI: 10.1007/s13277-016-5255-z

ACCESS

2016

OPEN

Tumor Biology, v. 37, p. 13743-13749

A guide for the analysis of long-term population growth in cancer.

Silva AO, Felipe KB, Villodre ES, Lopez PL, Lenz G.

DOI: 10.1007/s13277-016-5255-z

ACCESS

2016

OPEN

Journal of Cell Science, v. 129, p. 4622-4632

Ratiometric analysis of acridine orange staining in the study of acidic organelles and autophagy.

Thomé MP, Filippi-Chiela EC, Villodre ES, Migliavaca CB, Onzi GR, Felipe KB, Lenz G.

DOI: 10.1242/jcs.195057

ACCESS

2015

OPEN

Autophagy (Georgetown, TX), v. 11, p. 1099-1113

Single-cell analysis challenges the connection between autophagy and senescence induced by DNA damage.

Filippi-Chiela EC, Bueno e Silva MM, Thomé MP, Lenz G.

DOI: 10.1080/15548627.2015.1009795

ACCESS

2014

OPEN

Food and Chemical Toxicology, v. 63, p. 205-211

Quercetin promotes glioma growth in a rat model.

Zamin LL, Filippi-Chiela EC, Vargas J, Demartini DR, Meurer L, Souza AP, Bonorino C, Salbego C, Lenz G.

DOI: 10.1016/j.fct.2013.11.002

ACCESS

2014

OPEN

Biochemistry and Cell Biology (Print), v. 92, p. 297-304

Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells.

Vargas JE, Filippi-Chiela EC, Suhre T, Kipper FC, Bonatto D, Lenz G.

DOI: 10.1139/bcb-2014-0022

ACCESS

2013

OPEN

BMC Cancer (Online), v. 13, p. 147-157

Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells.

Filippi-Chiela EC, Thomé MP, Bueno e Silva MM, Pelegrini AL, Ledur PF, Garicochea B, Zamin LL, Lenz G.

DOI: 0.1186/1471-2407-13-147

ACCESS

2013

OPEN

Cell Death and Differentiation, v. 20, p. 1444-1454

Autophagy and genomic integrity.

Filippi-Chiela EC, Vessoni AT, Menck CFM, Lenz G.

DOI: 10.2174/18776132113036660014

ACCESS

2013

OPEN

Recent Patents on Medical Imaging, v. 3, p. 123-134

Recent Patents on Morphometric Analysis of Eukaryotic Cells.

Bueno e Silva MM, Filippi-Chiela E, Lenz G.

DOI: 10.2174/18776132113036660014

ACCESS

2012

OPEN

Oncology (Basel), v. 83, p. 75-82

Sensitization of Glioma Cells by X-Linked Inhibitor of Apoptosis Protein Knockdown.

Lopez PL, Filippi-Chiela EC, Silva AO, Cordero EA, Garcia-Santos D, Pelegrini AL, Reder GM, Barbieri NL, Lenz G.

DOI: 10.1159/000337978

ACCESS

2012

OPEN

Frontiers in Bioscience (Print), v. S4, p. 1017-1030

Endogenous anticancer mechanisms (EACMs).

Lenz G.

DOI: 10.2741/s315

ACCESS

2012

OPEN

Purinergic Signalling (Print), v. 8, p. 39-48

Extracellular ATP reduces tumor sphere growth and cancer stem cell population in glioblastoma cells.

Ledur PF, Villodre ES, Paulus R, Cruz LA, Flores DG, Lenz G.

DOI: 10.1007/s11302-011-9252-9

ACCESS

2012

OPEN

Plos One, v. 7, n. e42522

Nuclear Morphometric Analysis (NMA): Screening of Senescence, Apoptosis and Nuclear Irregularities.

Filippi-Chiela EC, Oliveira MM, Jurkovski B, Callegari-Jacques SM, da Silva VD, Lenz G.

DOI: 10.1371/journal.pone.0042522

ACCESS

2011

OPEN

Plos One, v. 6, n. e20849

Autophagy Interplay with Apoptosis and Cell Cycle Regulation in the Growth Inhibiting Effect of Resveratrol in Glioma Cells.

Filippi-Chiela EC, Villodre ES, Zamin LL, Lenz, G

DOI: 10.1371/journal.pone.0020849

ACCESS

2010

OPEN

Journal of Cellular Biochemistry (Print), v. 109, p. 983-991

Characterization of ATP-induced cell death in the GL261 mouse glioma.

Tamajusuku AS, Villodre ES, Paulus R, Coutinho-Silva R, Battasstini AM, Wink MR, Lenz G.

DOI: 10.1002/jcb.22478

ACCESS

2010

OPEN

Mutagenesis, v. 25, p. 447-454

Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest.

Pelegrini AL, Moura DJ, Brenner BL, Ledur PF, Maques GP, Henriques JA, Saffi J, Lenz G.

DOI: 10.1093/mutage/geq026

ACCESS

2010

OPEN

Medical Hypotheses, v. 75, p. 660-662

Transient oncogenes.

Lenz G.

DOI: 10.1016/j.mehy.2010.08.012

ACCESS

2009

OPEN

Cancer Science, v. 100, p. 1655-1662

Resveratrol and Quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells.

Zamin LL, Filippi-Chiela EC, Dillenburg-Pilla P, Horn F, Salbego C, Lenz G.

DOI: 10.1111/j.1349-7006.2009.01215.x

ACCESS

2005

OPEN

Brazilian Journal of Medical and Biological Research (Impresso), Brasil, v. 38, p. 1749-1757

The RNA interference revolution.

Lenz G.

DOI: 10.1590/S0100-879X2005001200003

ACCESS

2005

OPEN

The Journal of Biological Chemistry, Estados Unidos da America, v. 280, n.46, p. 38121-38124

Glutamatergic regulation of the p70S6 Kinase in primary mouse neurons.

Lenz G, Avruch J.

DOI: 10.1074/jbc.C500363200

ACCESS

2004

OPEN

Oncology (Basel), Suica, v. 67, n.5-6, p. 450-459

ERK, PKC and PI3K/Akt pathways mediate extracellular ATP and adenosine-induced proliferation of U138-MG glioma cell line.

Jacques-Silva MC, Bernardi A, Rodnight R, Lenz G.

DOI: 10.1159/000082930

ACCESS

2003

OPEN

Journal of Neuro-Oncology, USA, v. 64, p. 211-218

Extracellular nucleotides and nucleosides induce proliferation and increase nucleoside transport in human glioma cell lines.

Morrone FB, Jacques-Silva MC, Horn AP, Bernardi A, Schwartsmann G, Rodnight R, Lenz G.

DOI: 10.1023/A:1025699932270

ACCESS

2001

OPEN

Journal of Neurochemistry, Inglaterra, v. 77, n.4, p. 1001-1009

Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures.

Lenz G, Gonçalves D, Luo Z, Avruch J, Rodnight R, Neary JT.

DOI: 10.1046/j.1471-4159.2001.00299.x

ACCESS

2000

OPEN

British Journal of Pharmacology, v. 129, p. 927-936

P2Y Purinergic Receptor Subtypes Recruit Different MEK Activators In Astrocytes.

Lenz G, Gottfried C, Luo Z, Avruch J, Rodnight R, Nie WJ, Kang Y, Neary JT.

DOI: 10.1038/sj.bjp.0703138

ACCESS

1997

OPEN

Brain Research, v. 764, p. 188-196

Temporal profiles of the in vitro phosphorylation rate and immunocontent of glial fibrillary acidic protein (GFAP) after kainic acid-induced lesions in area CA1 of the rat hippocampus: Demonstration of a novel phosphoprotein associated with gliosis.

Lenz G, Manozzo L, Gottardo S, Achaval M, Salbego C, Rodnight R.

DOI: 10.1016/S0006-8993(97)00456-3

ACCESS

Publications

Temozolomide increases the generation of cell heterogeneity in ERK activity in glioma cells

CloVarS: a simulation of single-cell clonal variability

Heterogeneity generating capacity in tumorigenesis and cancer therapeutics.

CD73 mitigates ZEB1 expression in papillary thyroid carcinoma

Expression of key unfolded protein response genes predicts patient survival and an immunosuppressive microenvironment in glioblastoma.

The contribution of asymmetric cell division to phenotypic heterogeneity in cancer.

Mitochondrial response of glioma cell to temozolomide.

Asymmetric mitosis contributes to different migratory performance in sister cells.

The role of mitosis in generating fitness heterogeneity.

The crossroads of adenosinergic pathway and epithelial-mesenchymal plasticity in cancer.

Bioimaging approaches for quantification of individual cell behavior during cell fate decisions.

The Origins of Phenotypic Heterogeneity in Cancer.

Cancer Cell Fitness is Dynamic.

The role of dynamic phenotypes in cancer.

ENTPD5: identification of splicing variants and their impact on cancer survival.

Silencing of the transcription factors Oct4, Sox2, Klf4, c-Myc or Nanog has different effect on teratoma growth.

Dipyridamole impairs autophagic flux and exerts antiproliferative activity on prostate cancer cells.

esiCancer: Evolutionary in silico Cancer Simulator.

Transcriptional characterization of immunological infiltrates and their relation with glioblastoma patients overall survival.

Low Dose of Doxorubicin Potentiates the Effect of Temozolomide in Glioblastoma Cells.

Culture conditions defining glioblastoma cells behavior: what is the impact for novel discoveries?.

Vinblastine and antihelmintic mebendazole potentiate temozolomide in resistant gliomas.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Modulation of Autophagy by Calcium Signalosome in Human Disease.

The regrowth kinetic of the surviving population is independent of acute and chronic responses to temozolomide in glioblastoma cell lines.

Roles of OCT4 in tumorigenesis, cancer therapy resistance and prognosis.

A guide for the analysis of long-term population growth in cancer.

A guide for the analysis of long-term population growth in cancer.

Ratiometric analysis of acridine orange staining in the study of acidic organelles and autophagy.

Single-cell analysis challenges the connection between autophagy and senescence induced by DNA damage.

Quercetin promotes glioma growth in a rat model.

Inhibition of HDAC increases the senescence induced by natural polyphenols in glioma cells.

Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells.

Autophagy and genomic integrity.

Recent Patents on Morphometric Analysis of Eukaryotic Cells.

Sensitization of Glioma Cells by X-Linked Inhibitor of Apoptosis Protein Knockdown.

Endogenous anticancer mechanisms (EACMs).

Extracellular ATP reduces tumor sphere growth and cancer stem cell population in glioblastoma cells.

Nuclear Morphometric Analysis (NMA): Screening of Senescence, Apoptosis and Nuclear Irregularities.

Autophagy Interplay with Apoptosis and Cell Cycle Regulation in the Growth Inhibiting Effect of Resveratrol in Glioma Cells.

Characterization of ATP-induced cell death in the GL261 mouse glioma.

Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest.

Transient oncogenes.

Resveratrol and Quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells.

The RNA interference revolution.

Glutamatergic regulation of the p70S6 Kinase in primary mouse neurons.

ERK, PKC and PI3K/Akt pathways mediate extracellular ATP and adenosine-induced proliferation of U138-MG glioma cell line.

Extracellular nucleotides and nucleosides induce proliferation and increase nucleoside transport in human glioma cell lines.

Extracellular ATP stimulates an inhibitory pathway towards growth factor-induced cRaf-1 and MEKK activation in astrocyte cultures.

P2Y Purinergic Receptor Subtypes Recruit Different MEK Activators In Astrocytes.

Temporal profiles of the in vitro phosphorylation rate and immunocontent of glial fibrillary acidic protein (GFAP) after kainic acid-induced lesions in area CA1 of the rat hippocampus: Demonstration of a novel phosphoprotein associated with gliosis.

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