CloMA
Clonogenic Morphometric Analysis
CloMA, the Clonal Morphometric Analysis, is a tool for the automated analysis of clonogenic assays.
Instead of relying only on colony counts, CloMA extracts morphological and appearance-related features from individual colonies, allowing the characterization of clonogenic heterogeneity.
View on GitHub
CloMA workflow from image acquisition to colony-level morphometric analysis.
Analysis Workflow
From images to quantitative colony phenotypes
Image
Start with an image of a clonogenic assay.
Segmentation
Detect colonies and separate touching or overlapping colonies using image-processing methods.
Feature extraction
Extract a broad set of measurements describing the morphology and appearance of each colony.
Heterogeneity
Use colony-level measurements to characterize variation within and between experimental conditions.
Interfaces
Interactive analysis or automated processing
Napari Plugin
CloMA can be used as a plugin for Napari, providing an interactive environment for image preprocessing, segmentation and feature analysis.
- Interactive image visualization
- Segmentation and colony inspection
- Feature analysis
- CSV import and export
Command Line Interface
CloMA can also be executed through the command line, allowing analysis workflows to be integrated into automated and reproducible pipelines.
- Batch processing
- Automated workflows
- Reproducible analysis
- Large-scale experiments
Explore CloMA
Open-source tools for clonogenic image analysis
Access the source code, installation instructions and documentation through the CloMA GitHub repository.
Visit the GitHub Repository
