|
solute carrier family
|
transporter member
|
ion / molecule stoichometry
|
carried ions / molecules
|
expressed on ...
|
activators
|
inhibitors
|
notes
|
| SLC1 |
SLC1A1
/ EAAC1 / EAAT3 |
|
|
neuronal/epithelial |
|
|
|
| SLC1A2
/ EAAT2 / GLT-1 |
|
|
glial |
|
|
|
| SLC1A3
/ EAAT1 / GLAST / GLAST1 |
|
|
glial |
|
|
|
| SLC1A4
/ SATT / ASCT1 |
|
glutamate/neutral amino acid |
|
|
|
|
| SLC1A5
/ R16 / AAAT / ATBO / M7V1 / RDRC / ASCT2 / M7VS1 / RD114 virus receptor
/ baboon M7 virus receptor / neutral amino acid transporter B |
|
neutral amino acid |
|
|
|
|
| SLC1A6
/ EAAT4 |
|
high affinity aspartate/glutamate |
|
|
|
|
| SLC1A7 |
|
glutamate |
|
|
|
|
| SCL2 |
SLC2A1
/ GLUT1 |
|
glucose |
|
|
fluoretine |
|
| SLC2A2
/ GLUT2 |
|
glucose |
|
|
fluoretine |
|
| SLC2A3
/ GLUT3 |
|
glucose |
|
|
fluoretine |
|
| SLC2A4
/ GLUT4 |
|
glucose |
|
|
fluoretine |
|
| SLC2A5
/ GLUT5 |
|
glucose/fructose |
|
|
fluoretine |
|
| SLC2A6
/ GLUT6, HSA011372 |
|
glucose |
|
|
fluoretine |
|
| SLC2A7
/ GLUT7 |
|
glucose |
|
|
fluoretine |
|
| SLC2A8
/ GLUT8 / GLUTX1 |
|
glucose |
|
|
fluoretine |
|
| SLC2A9
/ GLUTX, GLUT9 |
|
glucose |
|
|
fluoretine |
|
| SLC2A10
/ GLUT10 |
|
glucose |
|
|
fluoretine |
|
| SLC2A11
/ GLUT11 |
|
glucose |
|
|
fluoretine |
|
| SLC2A12
/ GLUT12 |
|
glucose |
|
|
fluoretine |
|
| SLC2A13
/ HMIT / GLUT13 |
|
glucose |
|
|
fluoretine |
|
| SLC3 |
SLC3A1
/ D2H / ATR1 / NBAT / RBAT / CSNU1 |
|
cystine, dibasic and neutral amino acid |
|
|
|
|
| SLC3A2
/ 4F2 / CD98 / MDU1 / 4F2HC / NACAE |
|
dibasic and neutral amino acid |
|
|
|
|
| SLC4 |
SLC4A1
/ erythrocyte membrane protein band 3, Diego
blood group
/ DI / AE1 / BND3 / EPB3 / CD233 / EMPB3 / RTA1A / anion exchange protein
1 |
|
anion exchanger |
|
|
|
|
| SLC4A2/
erythrocyte membrane protein band 3-like 1 / AE2 / HKB3 / BND3L / NBND3
/ EPB3L1 |
|
anion exchanger |
|
|
|
|
| SLC4A3
/ AE3 / SLC2C |
|
anion exchanger |
|
|
|
|
| SLC4A4
/ KNBC / NBC1 / NBC2 / pNBC / HNBC1 / hhNMC |
|
sodium bicarbonate cotransporter |
|
|
|
|
| SLC4A5
/ NBC4 |
|
sodium bicarbonate cotransporter |
|
|
|
|
| SLC4A7
/ NBC2 / NBC3 / SBC2 / SLC4A6 |
|
sodium bicarbonate cotransporter |
|
|
|
|
| SLC4A8
/ NBC3 |
|
sodium bicarbonate cotransporter |
|
|
|
|
| SLC5 |
SLC5A1
/ NAGT / SGLT1 / D22S675 / Na+/glucose cotransporter 1 |
1:2
|
sodium/glucose cotransporter
Gal
Xil
dGlc
|
enterocytes |
|
fluorizine / phlorizin |
|
| SLC5A2
/ SGLT2 |
1:2
|
sodium/glucose cotransporter
Gal
Xil
dGlc
|
kidney |
|
fluorizine / phlorizin |
|
| SLC5A3
/ Na+/ myo-inositol
cotransporter 3 / SMIT / SMIT2 |
|
Na+/ myo-inositol
cotransporter |
|
|
|
|
| SLC5A4
/ SAAT1 / SGLT3 / DJ90G24.4 |
1:2
|
low affinity sodium glucose cotransporter
Gal
Xil
dGlc
|
|
|
fluorizine / phlorizin |
|
| SLC5A5
/ Na+ / I- symporter (NIS) |
2:1
|
Na+ / I- symporter
pertechnate (TcO4-), perrhenate (ReO4-),
perchlorate (ClO4-) and astatide (At-) |
thyroid tissues, nasal mucosa, stomach, salivary
glands, and lactating breast tissues |
|
|
expression in the thyroid gland is selectively down-regulated by T4
supplemental diet |
| SLC5A6
/ SMVT |
|
sodium / vitamin |
|
|
|
|
| SLC5A7
/ CHT / CHT1 / hCHT |
|
choline |
|
|
hemicholinium (HC-3) |
|
| SLC6 (neurotransmitter transporter) |
SLC6A1
/ GAT1, GABATR, GABATHG |
|
GABA |
|
|
tiagabine (Gabitril®)
giuvacine
nipecotic acid
b-alanine |
|
| SLC6A2
/ NET / NAT1 / NET1 / SLC6A5 |
|
norepinephrine |
|
|
binedaline
cocaine
(-) tramadol
SNRI
norepinephrine reuptake inhibitors (NRI) / noradrenaline
reuptake inhibitor (NARI / NaRI)
secondary-amine tricyclics (tricyclic antidepressants (TCA))
-
amoxapine (Asendin®, Asendin®, Defanyl®,
Moxadil®)
-
desipramine (Norpramin®, Pertofrane®,
Metylyl®, Nortimil®, Pertofrin®,
Sertofren®)
-
levoprotiline
-
maprotiline (Ludiomil®, Aneural®, Retinyl®,
Deprilept®, Maludil®)
-
nisoxetine
-
nitroxazepine (Sintamil®)
-
protriptyline (Vivactil®, Triptil®, Concordin®,
Concordine®, Maximed®)
-
tomoxetine / atomoxetine / LY139603 (Strattera®)
-
norclomipramine
-
oxaprotiline
-
lofepramine (Emdalen®, Gamanil®, Lomont®,
Tymelyt®)
-
reboxetine (Edronax®, Vestra®)
lacks immediate serotonergic effects
-
mianserin (Lantanon®)
-
viloxazine (Vivalan®)
noradrenergic and specific serotonergic antidepressants
(NaSSA) : an antidepressant drug that includes 4 fused rings in its
chemical structure.
-
mirtazepine (Remeron®, Norset®,
Zipsin®) (a tetracyclic antidepressant) : potent antagonist
of central a2-adrenergic autoreceptors,
and heteroreceptors and is an antagonist of serotonin 5-HT2
and 5-HT3
receptors. The result of these actions is to increase both noradrenergic
and specific (5-HT1)
serotonergic transmission
|
|
| SLC6A3
/ DAT / DAT1 |
|
dopamine |
|
|
cocaine
d-threo-methylphenidate
(d-MPH)
GBR12-395
dopamine reuptake inhibitors
(DRI) :
-
amineptine (Survector®, Directim®, Maneon)
-
bupropion / amfebutamone hydrochloride (Wellbutrin®,
Zyban®)
-
medifoxamine (Cledial®, Gerdasyl®)
-
pyrovalerone (Centroton®, Thymergix®)
dopamine and norepinephrin reuptake inhibitors (DNRI)
:
-
ciclazindol
-
dexmethylphenidate (Focalin®)
-
mazindol (Mazanor®, Sanorex®, Teronac®)
nomifensine (Merital, Alival®)
SDRI
|
|
| SLC6A4
/ HTT, SERT |
|
serotonin |
|
tianeptine (Ardix®, Stablon®) |
serotonin and norepinephrin reuptake inhibitors (SNRI)
:
-
tertiary-amine tricyclics / tricyclic antidepressants
(TCA) :
-
amitriptyline (Elavil®, Endep®,
Etrafon®, Amitril®, Amitrip®,
Domical®, Etravil®, Laroxil®,
Laroxyl®, Lentizol®, Levate®,
Miketorin®, Novotriptyn®, Pinsanu®,
Quietal®, Redomex®, Saroten®,
Tridep®, Triptizol®, Tryptizol®,
Tryptal®, Uxen®, Vanatrip®;
Limbitrol® in combination with chlordiazepoxide;
Triavil®, Etrafon® in combination with perphenazine)
-
butriptyline (Evadyne®, Evadene®, Centrolyse®)
-
clomipramine (Anafranil®, Clofranil®, Clomifril®,
Clopress®, Gromin®, Hydiphen®,
Placil®)
-
demexiptiline (Tinoran®, Deparon®)
-
dibenzepine (Noveril®, Ecotril®, Victoril®)
-
dothiepin / dosulepin (Prothiaden®, Arpin®,
Idom®)
-
doxepin (Adapin®, Sinequan®, Aponal®,
Poldoxin®, Quitaxon®, Desidox®,
Doneurin®, Doxal®, Doxedyn®)
-
duloxetine (Cymbalta®)
-
imipramine (Janimine®, Antideprin®,
Ethipramine®, Imavate®, Melipramine®,
Mipralin®, Pryleugan®, Sedacoroxen®,
Venefon®, Nisorex®, Tofranil®)
=> desmethylimipramine (NRI)
-
indeloxazine (Elen®)
-
milnacipram (Ixel®)
-
nortriptyline (Aventyl®, Pamelor®)
-
noxiptiline (Nogedal®)
-
quinupramine (Kinupril®, Adeprim®, Kevopril®)
-
itrimipramine (Surmontil®, Rhotrimine®)
selective serotonin noradrenalin reuptake inhibitors
(SSNRI) / serotonin noradrenergic reuptake inhibitors (SNaRIs)
-
venlafaxine (Effexor®, Efexor®,
Trevilor®, Vandral®)
benzopyridodiazepine :
atypical antidepressants / serotonin2-antagonists/serotonin
reuptake inhibitors (SARI) / dual serotonergic antidepressants (DSA)
(also acting as 5-HT2
antagonists) :
-
nefazodone (Serzone®, Dutonin®, Nefadar®)
-
trazodone (Desyrel®, Trittico®,
Molipaxin®, Pragmarel®, Thombran®,
Trazodil®, Trazolan®)
-
ziprasidone (Geodon®, Zeldox®)
selective serotonin reuptake inhibitors (SSRI)
:
-
cericlamine
-
citalopram (Celexa®, Cipramil®,
Seropram®, Elopram®)
-
escitalopram (Lexapro®, Cipralex®)
-
clovoxamine
-
dapoxetine
-
femoxetine (Malexil®)
-
fluoxetine (Prozac®, Sarafem®,
Lovan®, Prodep®, Deproxin®,
Fluoxac®, Fluoxil®, Zactin®,
"bye bye blue")
-
fluvoxamine (Fevasin®, Floxyfral®,
Luvox®)
-
indalpine (Upstene®)
-
litoxetine
-
viqualine
-
paroxetine (Paxil®, Seroxat®,
Aropax®, Deroxat®)
-
zimeldine (Zelmid®)
serotonin / dopamine reuptake inhibitors (SDRI)
:
-
sertraline (Zoloft®, Lustral®)
(+) tramadol
roxindole
|
|
| SLC6A6
/ TAUT |
|
taurine |
|
|
|
|
| SLC6A7
/ PROT |
|
L-proline |
|
|
|
|
| SLC6A8
/ CT1 / CRTR |
|
creatine |
|
|
|
|
| SLC6A9
/ GLYT1 |
|
glycine |
|
|
sarcosine |
|
| SLC6A10
/ CT2 / CT-2 |
|
creatine |
|
|
|
|
| SLC6A11
/ GAT3 / GAT-3 |
|
GABA |
|
|
|
|
| SLC6A12
/ BGT1, BGT-1 |
|
betaine/GABA |
|
|
|
|
| SLC6A13
/ GAT2 / GAT-2 |
|
GABA |
|
|
|
|
| SLC6A14
/ ATB(0+) |
|
|
|
|
|
|
| SLC6A15: |
|
|
|
|
|
|
| SLC6A16 |
|
|
|
|
|
|
| SLC7 (cationic amino acid transporter, y+ system) |
SLC7A1
/ ERR, ATRC1, CAT-1, HCAT1, REC1L |
|
|
|
|
|
| SLC7A2
/ ATRC2, CAT-2, HCAT2 |
|
|
|
|
|
|
| SLC7A3
/ ATRC3, CAT-3, FLJ14541 |
|
|
|
|
|
|
| SLC7A4
/ CAT4, CAT-4, HCAT3 |
|
|
|
|
|
|
SLC7A5
/ E16, CD98, LAT1, MPE16, D16S469E
/ 4F2 light chain |
|
|
|
|
|
|
| SLC7A6
/ LAT3, LAT-2, y+LAT-2, KIAA0245 |
|
|
|
|
|
|
| SLC7A7
/ LPI, LAT3, Y+LAT1, y+LAT-1 |
|
|
|
|
|
|
| SLC7A8
/ LAT2, LPI-PC1 |
|
|
|
|
|
|
| SLC7A9
/ CSNU3 |
|
cationic amino acid |
|
|
|
|
| SLC7A10
/ asc-1, HASC-1, FLJ20839 |
|
|
|
|
|
|
| SLC7A11
/ xCT, CCBR1 |
|
|
|
|
|
|
| SLC8 (sodium-calcium exchanger) |
SLC8A1
/ NCX1 / sodium-calcium exchanger 1 |
|
|
|
|
SEA0400 |
|
| SLC8A2
/ NCX2, KIAA1087, DKFZp761D171, Na+/Ca2+-exchanging
protein Nac2, sodium-calcium exchanger 2 |
|
|
|
|
|
|
| SLC8A3
/ NCX2, NCX3 / sodium-calcium exchanger 3 |
|
|
|
|
|
|
| SLC9 (sodium/hydrogen exchanger) |
SLC9A1
(antiporter, Na+/H+, amiloride sensitive) / APNH / NHE1 |
1:1
|
type A intercalated cells; basolateral membranes of intestinal cellsref |
|
|
|
amiloride (in combination with hydrochlorothiazide
in Moduretic®) |
| SLC9A2
/ NHE2 |
|
apical membranes of the intestinal epitheliaref |
|
|
|
|
| SLC9A3
/ NHE3 |
|
apical membranes of the intestinal epitheliaref |
|
|
|
|
| SLC9A4
/ NHE4 |
|
|
|
|
|
|
| SLC9A5
/ NHE5 |
|
|
|
|
|
|
| SLC9A6
/ NHE6 / KIAA0267 |
|
|
|
|
|
|
| SLC9A7
/ NHE7 |
|
|
|
|
|
|
| SLC10 (sodium/bile acid cotransporter family |
SLC10A1
/ Na+-taurocholate cotransporter polypeptide (NTCP / NTCP1) |
|
a-amanitine |
|
|
|
|
| SLC10A2
/ ASBT / ISBT, NTCP2 |
|
|
|
|
|
|
| SLC11 (proton-coupled divalent metal ion transporters) |
SLC11A1
/ LSH, NRAMP, NRAMP1 |
|
|
|
|
|
|
| SLC11A2
/ DCT1 / divalent metal transporter 1 (DMT1) / NRAMP2 |
|
Cd2+
Mn2+ |
|
|
|
|
| SLC11A3
/ FPN1, MTP1, IREG1 / ferroportin 1 |
|
|
|
|
|
|
| SLC12 |
SLC12A1
(sodium/potassium/chloride transporters) / isoform 2 / BSC1, NKCC2 / ENCC2 |
1:1:2
(in squid 2:1:3)
|
|
apical membrane of the thick ascending limb of Henle's loop and macula
densa |
|
sulfonamides :
-
furosemide (Lasix®)
-
bumetanide (Bumex®)
sulfonylurea :
phenoxyacetic acid :
-
ethacrynic acid (Edecrin®)
muzolimine
azosemide
piretanide (Arelix®)
tripamide |
|
| SLC12A2
(sodium/potassium/chloride transporters) / BSC / BSC2 / NKCC1 / ENCC3 |
|
|
secretory epithelia |
|
|
|
| SLC12A3
(sodium/chloride transporters) / TSC, NCCT / thiazide-sensitive Na-Cl cotransporter |
|
|
distal convoluted tubule |
|
thiazide diuretics :
benzothiazedines :
non-benzothiazedines :
-
benathiazide (Exna®)
-
chlorthalidone (Hygroton®)
-
hydrochlorothiazide (Hydrodiuril®;
in combination with amiloride in Moduretic®;
Losazid® in combination with losartan;
Zestoretic® in combination with lisinopril)
-
hydroflumethiazide (Saluron®)
-
hydromethiazide (Diucardin®)
-
methyclothiazide (Enduron®)
-
polythiazide (Renese®)
-
quinethiazone (Hydromox®)
-
trichlormethiazide (Naqua®)
-
indapammide (Lozol®)
-
metolazone (Mykrox®, Zaroxolyn®)
-
quinemethazone (Hydromox®)
-
bendroflumethiazide (Naturetin®)
|
|
| SLC12A4
(potassium/chloride transporters) / KCC1 |
|
|
|
|
|
|
| SLC12A5
(potassium-chloride transporter) / KCC2, KIAA1176 |
|
|
|
|
|
|
| SLC12A6
(potassium/chloride transporters) / KCC3, ACCPN, KCC3A, KCC3B, DKFZP434D2135 |
|
|
|
|
|
|
| SLC12A7
(potassium/chloride transporters) / KCC4, DKFZP434F076 |
|
|
|
|
|
|
| SLC12A8
(potassium/chloride transporters) / FLJ23188 |
|
|
|
|
|
|
| SLC13 |
SLC13A1
(sodium/sulfate symporters) / NAS1, NaSi-1 |
|
|
|
|
|
|
| SLC13A2
(sodium-dependent dicarboxylate transporter) / NADC1, NaDC-1 |
|
|
|
|
|
|
| SLC13A3
(sodium-dependent dicarboxylate transporter) / NADC3, SDCT2 |
|
|
|
|
|
|
| SLC13A4
(sodium/sulfate symporters) / SUT1, SUT-1 |
|
|
|
|
|
|
| SLC14 (urea transporter) |
SLC14A1
(Kidd blood group) / RACH1 / JK, UT1, UTE, RACH1, UT-B1 |
|
|
|
|
|
|
| SLC14A2
/ UT2, UTR, HUT2 |
|
|
|
|
|
|
| SLC15 |
SLC15A1
/ PEPT1, HPECT1, HPEPT1 |
|
oligopeptide transporter |
|
|
|
|
| SLC15A2
/ PEPT2 |
|
H+/peptide transporter |
|
|
|
|
| SLC16 (monocarboxylic acid transporters) |
SLC16A1
/ MCT, MCT1 |
|
|
|
|
|
|
| SLC16A2
/ XPCT, DXS128, DXS128E |
|
|
|
|
|
|
| SLC16A3
/ MCT3, MCT4 |
|
|
|
|
|
|
| SLC16A4
/ MCT4 |
|
|
|
|
|
|
| SLC16A5
/ MCT5 |
|
|
|
|
|
|
| SLC16A6
/ MCT6 |
|
|
|
|
|
|
|
SLC16A7
/ MCT2 |
|
|
|
|
|
|
| SLC16A8
/ MCT3 |
|
|
|
|
|
|
| SLC16A10
/ TAT1 / PRO0813 |
|
|
|
|
|
|
| SLC17 (sodium phosphate) |
SLC17A1
/ NPT1 / NAPI-1 |
|
As5+ |
|
|
|
|
| SLC17A2
/ SLC34A1 / NPT2 / SLC11 / NAPI-3 |
|
As5+ |
|
|
|
|
| SLC17A3
/ NPT4 |
|
As5+ |
|
|
|
|
| SLC18 |
SLC18A1
/ CGAT, VAT1, VMAT1 |
|
vesicular monoamine |
|
|
|
|
| SLC18A2
/ SVAT, SVMT, VAT2, VMAT2 |
|
vesicular monoamine |
|
|
|
|
| SLC18A3
/ VACHT |
|
vesicular acetylcholine |
|
|
vesamicol |
|
| SLC19 |
SLC19A1
/ CHMD, FOLT, IFC1, REFC, RFC1 / reduced folate carrier |
|
folate |
|
|
|
|
| SLC19A2 |
|
thiamine |
|
|
|
|
| SLC20 |
SLC20A1
/ PIT1, gibbon ape leukemia virus receptor 1 (GLVR1) |
|
phosphate
As5+ |
|
|
|
|
| SLC20A2
/ gibbon ape leukemia virus receptor 2 (GLVR2), MLVAR / PIT2 |
|
phosphate
As5+ |
|
|
|
|
| SLC20A3
/ SLC25A1 / CTP |
|
mitochondrial citrate |
|
|
|
|
| SLC21 |
SLC21A1 |
|
organic anion |
|
|
|
|
| SLC21A2
/ PGT |
|
prostaglandin |
|
|
|
|
| SLC21A3
/ OATP, OATP-A |
|
organic anion |
|
|
|
|
| SLC22 |
SLC22A1
/ OCT1 / HOCT1
SLC22A1L |
|
organic cation
imatinib |
|
|
|
|
| SLC22A2
/ OCT2 |
|
organic cation |
|
|
|
|
| SLC22A3
/ EMT, EMTH, OCT3 |
|
monoamine |
extraneuronal |
|
|
|
| SLC22A4
/ OCTN1 / ETT / MGC34546 |
|
organic cations :
-
ergothioneine (ET) (all of which is absorbed from food, is an intracellular
antioxidant with metal ion affinity) is transported >100 times more efficiently
than tetraethylammonium and carnitineref
|
erythrocytes and monocytes (protective role in chronic inflammatory
diseases) |
|
|
|
| SLC22A5
/ OCTN2 |
|
high-affinity sodium dependent organic cation/carnitine |
|
|
|
|
| SLC22A6
/ OAT1, PAHT, HOAT1, ROAT1, MGC45260 |
uric acid |
organic anion
|
basolateral side of the proximal tubule |
|
probenecid (Benecid®, Benemid®) |
|
| SLC22A7
/ NLT, OAT2, MGC24091, MGC45202 / liver-specific transporter |
|
organic anion |
|
|
|
|
| SLC22A8
/ OAT3, MGC24086 |
|
organic anion
-
p-aminohippurate (PAH)
-
estrone sulfate
-
indoxyl sulfate
|
|
|
|
|
| SLC22A9
/ OAT4, HOAT4 |
|
organic anion/cation |
|
|
|
|
| SLC22A10
/ OAT5, hOAT5 |
|
organic anion/cation |
|
|
|
|
| SLC22A11
/ OAT4, hOAT4, MGC34282 |
|
organic anion/cation |
|
|
|
|
| SLC22A12
/ RST, OAT4L, URAT1 / urate transporter 1 |
|
organic anion/cation |
|
|
|
|
| SLC23 |
SLC23A1
/ NBTL1, SVCT2, YSPL2, SLC23A2, KIAA0238 / sodium-dependent vitamin
C
transporter-2 |
|
nucleobase
sodium-dependent vitamin C |
|
|
|
|
SLC23A2
/ SVCT1, yolk sac permease-like molecule 3 (YSPL3), SLC23A1, MGC22361 /
sodium-dependent vitamin C
transporter-1 |
|
nucleobase
sodium-dependent vitamin C |
|
|
|
|
| SLC24 (sodium/potassium/calcium exchanger) |
SLC24A1
/ NCKX, RODX, NCKX1, KIAA0702 |
|
|
|
|
|
|
| SLC24A2
/ NCKX2 |
|
|
|
|
|
|
| SLC24A3
/ NCKX3 |
|
|
|
|
|
|
| SLC24A4
/ NCKX4 |
|
|
|
|
|
|
| SLC25 (mitochondrial carrier) |
SLC25A1
/ CTP, SLC20A3 |
|
citrate |
|
|
|
|
| SLC25A3
/ PHC |
|
phosphate
As5+ |
|
|
|
|
| SLC25A4
/ T1, ANT, ANT1, PEO2, PEO3, Heart-skeletal muscle |
|
adenine nucleotide |
|
|
|
|
| SLC25A5
/ T2, T3, ANT2 / 2F1 |
|
adenine nucleotide |
|
|
|
|
| SLC25A6
/ ANT3, ANT3Y |
|
adenine nucleotide |
|
|
|
|
| SLC25A7
/ termogenin / uncoupling protein 1 (UCP-1) |
|
proton |
inner mitochondrial membrane of brown adipocyte tissue (BAT) |
|
|
|
| SLC25A8
/ termogenin / uncoupling protein 2 (UCP-2) |
|
proton |
many tissues, with the greatest expression in skeletal muscle |
|
|
|
| SLC25A9
/ termogenin / uncoupling protein 3 (UCP-3) |
|
proton |
skeletal muscle |
|
|
|
| SLC25A10
/ dicarboxylate ion carrier (DIC) |
|
dicarboxylate |
|
|
|
|
| SLC25A11
/ OGC, SLC20A4 |
|
oxoglutarate |
|
|
|
|
| SLC25A12
/ ARALAR, Aralar, ARALAR1 |
|
Aralar |
|
|
|
|
| SLC25A13
/ CTLN2, CITRIN, ARALAR2 |
|
|
|
|
|
|
| SLC25A14
/ UCP5, BMCP1 |
|
|
brain |
|
|
|
| SLC25A15
/ HHH, ORNT1, D13S327 |
|
ornithine |
|
|
|
|
| SLC25A16
/ Graves
disease
autoantigen / GDA, GDC, ML7, hML7, HGT.1, D10S105E |
|
|
|
|
ruthenium red |
|
| SLC25A17
/ peroxisomal membrane protein, 34kDa (PMP34) |
|
|
|
|
|
|
| SLC25A18 |
|
glutamate |
|
|
|
|
| SLC25A19
/ DNC, MUP1, MCPHA |
|
deoxynucleotide |
|
|
|
|
| SLC25A20
/ CAC, CACT |
|
carnitine/acylcarnitine |
|
|
|
|
| SLC25A21 |
|
oxodicarboxylate |
|
|
|
|
| SLC26 |
SLC26A1
/ EDM4, SAT1, SAT-1 |
|
sulfate |
|
|
|
| SLC26A2
/ DTD, EDM4, DTDST, D5S1708 / diastrophic dysplasia sulfate transporter |
|
sulfate |
|
|
|
|
| SLC26A3
/ CLD, DRA |
|
Cl-/HCO3- exchange |
highly expressed in colon and cecum and to a lesser extent in the small
intestineref1,
ref2
and localized to the apical membranes of colonic surface cells and the
upper regions of the cryptsref |
|
|
|
| SLC26A4
/ PDS / DFNB4 / pendrin |
|
|
|
|
|
|
| SLC26A5
/ PRES: prestin (motor protein) |
|
|
|
|
|
|
SLC26A6
/ DKFZp586E1422 / pendrin L1 / anion transporter 1
pendrin-like protein 1 / sulfate anion transporter |
|
|
|
|
|
|
| SLC26A7
/ SUT2 / transporter |
|
sulfate anion |
|
|
|
|
| SLC26A8
/ testis anion transporter 1 (TAT1) |
|
anion |
|
|
|
|
| SLC26A9 |
|
|
|
|
|
|
| SLC26A10 |
|
|
|
|
|
|
| SLC26A11 |
|
|
|
|
|
|
| SLC27 (fatty acid transporter) |
SLC27A1
/ fatty acid transport protein 1 (FATP, FATP1) (up-regulated by PPAR-a) |
|
fatty acid |
|
|
|
|
| SLC27A2
/ VLCS, FATP2, VLACS, FACVL1 / very-long-chain acyl-CoA synthetase / very
long-chain fatty-acid-coenzyme A ligase 1 |
|
|
|
|
|
|
| SLC27A3
/ FATP3 / MGC4365 |
|
|
|
|
|
|
| SLC27A4
/ FATP4 |
|
|
|
|
|
|
| SLC27A5
/ FATP5 / VLACSR / VLCSH2 / VLCS-H2 |
|
|
|
|
|
|
| SLC27A6
/ FATP6 |
|
|
|
|
|
|
| SLC28 (sodium-coupled nucleoside transporter) |
SLC28A1
/ adenosine
transporter |
|
sodium-coupled nucleoside transporter for pyrimidine nucleosides and
adenosine |
|
|
dipyridamole (Antistenocardin®,
Persantine®; Aggrenox® when coupled to acetylsalicylic
acid) |
|
| SLC28A2
/ CNT2 / HCNT2 / SPNT1 |
|
|
|
|
|
|
| SLC28A3
/ CNT3 |
|
|
|
|
|
|
| SLC29 (nucleoside transporters) |
SLC29A1
/ type 1 equilibrative nucleoside transporter (ENT1) / GC2 |
|
|
|
|
|
|
| SLC29A2
/ ENT2 / DER12 / HNP36 |
|
|
|
|
|
|
| SLC30 (zinc transporter) |
SLC30A1
/ ZNT1 |
|
Zn |
|
|
|
|
| SLC30A2
/ ZNT2 |
|
Zn |
|
|
|
|
| SLC30A3
/ ZNT3 |
|
Zn |
|
|
|
|
| SLC30A4
/ ZNT4 |
|
Zn |
|
|
|
|
| SLC30A5
/ ZNT5 / ZTL1, ZNTL1 / MGC5499 / FLJ12496 / FLJ12756 |
|
Zn |
|
|
|
|
| SLC311 (copper transporters) |
SLC31A1
/ CTR1 / COPT1 |
|
Pt |
|
|
|
|
| SLC31A2
/ CTR2 / COPT2 / SLC13A2 |
|
|
|
|
|
|
| SLC32 |
SLC32A1
/ VGAT |
|
GABA
vesicular |
|
|
|
|
| SLC34 (sodium phosphate) |
SLC34A1
/ NPT2 / SLC11 / NAPI-3 / SLC17A2 |
|
As5+ |
|
|
|
|
| SLC34A2
/ NAPI-3B / SLC17A# / type II sodium-dependent phosphate transporter 3b |
|
As5+ |
|
|
|
|
| SLC35 |
SLC35A1
/ CST / hCST / CMPST |
|
CMP-sialic acid (CMP-Sia) |
|
|
|
|
| SLC35A2
/ UGT / UGAT / UGT1 / UGT2 / UGTL / UGALT |
|
UDP-galactose (UDP-Gal) |
|
|
|
|
| SLC35A3 |
|
UDP-N-acetylglucosamine (UDP-GlcNAc) |
|
|
|
|
| SLC35C1
/ Golgi GDP-fucose transporter 1 |
|
GDP-fucose |
|
|
|
|
| SLC36 |
SLC36A1
/ PAT1 / LYAAT1 |
|
proton/amino acid symporter |
|
|
|
|
| SLC36A2
/ tramdorin 1 / Tramd1 / PAT2 |
|
|
Schwann cells |
|
|
|
| SLC37 |
SLC37A1
/ G3PP |
|
glycerol-3-phosphate |
|
|
|
|
| SLC38 |
SLC38A1
/ ATA1, NAT2, SAT1 |
|
|
|
|
|
|
| SLC38A2
/ ATA2 / SAT2 / PRO1068 / KIAA1382 |
|
|
|
|
|
|
| SLC38A3
/ G17 / SN1 |
|
|
|
|
|
|
| SLC38A4
/ ATA3 / NAT3 / PAAT / FLJ10191 |
|
|
|
|
|
|
| SLC38A5
/ SN2 / JM24 |
|
|
|
|
|
|
|
SLC38A6
/ NAT1 |
|
|
|
|
|
|
