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SERVICES Molecular Biology

Central to the activities developed at CBiot since its foundation, Molecular Biology consists of the study of the structure and function of molecules and macromolecular systems, particularly in the molecular information flow in living organisms from their genetic material. In addition to being essential in the commercial production of Taq DNA polymerase in Brazil in the 1990s by CBiot, this expertise allowed us to integrate the "Genolyptus: Brazilian Eucalyptus Genome Research Network," which included 14 companies from the forestry sector and eight Brazilian research institutions. We coordinated the sequencing of the eucalyptus transcriptome, resulting in the publication "The Genome of Eucalyptus grandis" in the journal Nature in 2014, paving the way for the development of the first transgenic eucalyptus cultivars. In addition to these contributions, CBiot researchers have also been involved in rice improvement, mainly in the biofortification of its seeds with iron and zinc, and were responsible for producing the first genetically fortified rice plants in Rio Grande do Sul.

The use of molecular biology techniques has allowed CBiot researchers to accumulate solid expertise in various areas of knowledge and applications. For example, it enabled us to pioneer the description of the pathogenesis of filamentous fungi in ticks, constituting a potential tool for biological control of this important pathogen in Brazilian and global livestock. Finally, to support these research efforts and enhance future advancements, CBiot established the Multi BioMol Lab - CBiot Molecular Biology Multi-User Laboratory, equipped with the necessary infrastructure for studies and technology developments in molecular biology, also serving as support for companies incubated at IECBiot.

Publications

One of the indicators of the impact of CBiot's activities on Gaúcho and Brazilian societies is the quantity and quality of articles published by our researchers in highly relevant international journals, often subject to interactions with the productive sector.

Most of these works are associated with the training activities of our students into new high-level researchers, ready to tackle societal problems, whether in teaching, research institutes, or technology-based companies.

  • A longitudinal transcriptomic analysis of Rhipicephalus microplus midgut upon feeding| 2024 | TICKS AND TICK-BORNE DISEASESLu, Stephen and Waldman, Jessica and Parizi, Luis Fernando and Vaz Junior, Itabajara da Silva and Tirloni, Lucas
  • Xanthan-carrageenan film containing sesame seed oil: A nanocomposite pharmaceutical platform for trichomoniasis treatment| 2024 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULESSaccol, Camila Parcianello and Cervi, Veronica Ferrari and Blume, Julia Carine and Menezes, Agata Giuseppe and Apel, Miriam Anders and da Rosa, Lucas Saldanha and Tasca, Tiana and Cruz, Leticia
  • The use of gene expression datasets in feature selection research: 20 years of inherent bias?| 2024 | WILEY INTERDISCIPLINARY REVIEWS-DATA MINING AND KNOWLEDGE DISCOVERYGrisci, Bruno I. and Feltes, Bruno Cesar and Poloni, Joice de Faria and Narloch, Pedro H. and Dorn, Marcio
  • Theoretical models of staurosporine and analogs uncover detailed structural information in biological solution| 2024 | JOURNAL OF MOLECULAR GRAPHICS \& MODELLINGFontana, Crisciele and de Meirelles, Joao Luiz and Verli, Hugo
  • Detection of Trichomonas vaginalis by Allplex™ STI Essential Assay (Seegene) in clinical samples from the Brazilian public health system users| 2024 | EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY \& INFECTIOUS DISEASESFreitas, Mariana Dicki and Cardoso, Fernanda Gomes and Rigo, Graziela Vargas and Machado, Hanalydia de Melo and Bazzo, Maria Luiza and Tasca, Tiana

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