VIROTHERAPY : REPLICATION-SELECTIVE (OR CONDITIONALLY REPLICATING) LYTIC VIRUSES

Replication-selective oncolytic viruses are used for cancer therapy (viral oncolysis). Attenuated viruses with tumor specificity have attracted considerable interest as novel anticancer agents, and clinical testing of several such agents is under wayref. Tumor selectivity of these viruses has been attributed to various intracellular restrictions to their life cycles that are strongly inhibitory to virus propagation in nontransformed cells but that are overridden by cellular factors present in neoplastic cellsref1, ref2, ref3, ref4, ref5. A pronounced bystander effect caused by self-perpetuating infection of adjacent cells after cytolysis of primary targeted cells is considered a further advantage.


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