Research Lines

Telefone - Dra. Ana Maria Oliveira Battastini   E-mail - Dra. Ana Maria Oliveira Battastini   Lattes - Dra. Ana Maria Oliveira Battastini

Dra. Ana Maria Oliveira Battastini

Curriculum

• Research Productivity Scholarship 1B | Master’s Advisor | Doctoral Supervisor
• PhD in Sciences (Biochemistry) by Universidade Federal do Paraná, Brazil (1996)
• Full Professor at Universidade Federal do Rio Grande do Sul, Brazil

Research Line

STUDY OF PURINERGIC SIGNALING IN TUMORS AND PATHOLOGIES IN THE CENTRAL NERVOUS SYSTEM AND ITS RELATIONSHIP WITH IMUNE SYSTEM

In this line of research we have addressed purinergic signaling in four main aspects: a) evaluation of the enzymatic activity and expression of ecto-nucleotidases (NTPDases / CD39, ecto-5′-nucleotidase / CD73) and purinergic receptor expression and functionality of tumors in the nervous system (gliomas and meduloblatomas) and in the bladder; B) the study of the role of the enzymes NTPDase1 / CD39 and ecto-5′-NT / CD73 in cells of the immune system; C) The enzyme ecto-5′-nucleotidase as potential new pharmacological target in cancer. In this sense we have made a molecular modeling approach in the search for new molecules inhibiting this enzyme and, d) the role of purinergic receptors, especially P2X7, in central nervous system disorders involving neuroinflammation and neuroprotection.

Concentration Areas: Cellular Biology

Telefone - Dr. André Quincozes dos Santos   E-mail - Dr. André Quincozes dos Santos   Lattes - Dr. André Quincozes dos Santos

Dr. André Quincozes dos Santos

Curriculum

• 1D Research Productivity Scholarship | Master’s Advisor | Doctoral Supervisor
• PhD in Biological Sciences (Biochemistry) from the Universidade Federal do Rio Grande do Sul, Brazil (2010)
• Post-doctorate from the Universidade Federal do Rio Grande do Sul, Brazil (2014)
• Adjunct Professor I at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

NEUROTOXICITY AND GLIOPROTECTION

Astrocytes are extremely versatile cells, fundamental for the maintenance of homeostasis in the central nervous system. The use of astrocyte cultures from adult and aged animals is an important new tool in the understanding of astrocytic functionality related to aging and, consequently, age-related diseases. In this line, we investigate the mechanisms of glioprotection against neurotoxic conditions both in vivo and in vitro, as well as the glioprotective potential of antioxidants.

Concentration Areas: Neurochemistry, Neuropharmacology and Behaviour

Telefone - Dra. Angela Terezinha de Souza Wyse   E-mail - Dra. Angela Terezinha de Souza Wyse   Lattes - Dra. Angela Terezinha de Souza Wyse

Dra. Angela Terezinha de Souza Wyse

Curriculum

• Research Productivity Scholarship 1A | Master’s Advisor | Doctoral Advisor
• PhD in Sciences (Biochemistry) from the Universidade Federal do Paraná, Brazil (1995)
• Full Professor at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

NEUROBIOLOGY OF BRAIN DISEASES AND THEIR NEUROPROTECTION

Investigation of neurochemical, morfological and behavioral mechanisms in experimental model mimicking physiological and/or pathological conditions, focusing on tissue accumulation of neurotoxic compounds accumulated in innate errors of the metabolism, mainly homocysteine, an amino acid considered a risk factor for neurometabolic, neurodegenerative, psychiatric, cancer and cerebral and cardiac ischemia, with emphasis on neuroprotection. The role of Na +, K + -ATPase, bioenergetics, cholinergic and glutamatergic homeostasis, oxidative and inflammatory status in the pathophysiology of these diseases, as well as the neurobiology of menopause are also studied. Biochemical and behavioral mechanisms of methylphenidate are also investigated at central and peripheral levels

Concentration Areas: Neurochemestry, Neuropharmacology, and Behaviour: Innate Errors of the Metabolism

Telefone - Dra. Carla Dalmaz   E-mail - Dra. Carla Dalmaz   Lattes - Dra. Carla Dalmaz

Dra. Carla Dalmaz

Curriculum

• Research Productivity Scholarship 1B | Master’s Advisor | Doctoral Advisor
• PhD in Sciences (Biochemistry) from the Universidade Federal do Paraná, Brazil (1989)
• Post-doctorate from the University of California, United States (1992)
• Full Professor at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

STRESS NEUROBIOLOGY

Studies the impact of stress at different development stages on behavior, using animal models. Stress at sensitive periods during postnatal development leads to nervous system programming with distinct behavioral outcomes, including memory, attention, and anxiety. These changes are object of study of the group. Neurochemical parameters related to such effects, such as oxidative stress and neurotransmitter systems, are also studied. The effects on eating behavior and metabolism and the interaction of stress during development with the consumption of palatable diets are also the focus of the laboratory study.

Concentration Areas: Neurochemistry, Neuropharmacology and Behaviour

Telefone - Dr. Carlos Alberto Saraiva Gonçalves   E-mail - Dr. Carlos Alberto Saraiva Gonçalves   Lattes - Dr. Carlos Alberto Saraiva Gonçalves

Dr. Carlos Alberto Saraiva Gonçalves

Curriculum

• Research Productivity Scholarship 1A | Master’s Advisor | Doctoral Supervisor
• PhD in Sciences (Biochemistry) from the Universidade Fedeal do Paraná, Brazil (1992)
• Post-doctorate from the University of Newcastle, Australia (1995)
• Full Professor at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

PROTEIN S100B IN NEUROGLIAL PLASTICITY

Astrocytes, the most abundant cells of the CNS, act on metabolic regulation, antioxidant defense, synaptic modulation and inflammatory response. S100B, a calcium binding protein, is secreted by astrocytes and exerts trophic (or toxic) activity on neighboring cells via RAGE and TLR receptors. Changes in the expression and activity of this protein have been associated with several neurodegenerative diseases (e.g., Alzheimer’s disease and diabetes mellitus) and other neuropsychiatric disorders. In this line we investigated S100B and other glial proteins (GFAP, glutamine synthetase, calcineurin and ApoE) in several clinical situations, dementia models and neuroprotection strategies.

Concentration Areas: Nutrition, Metabolism, Oxidative Stress

Telefone - Dr. Carlos Alexandre Netto   E-mail - Dr. Carlos Alexandre Netto   Lattes - Dr. Carlos Alexandre Netto

Dr. Carlos Alexandre Netto

Curriculum

• Research Productivity Scholarship 1A | Master’s Advisor | Doctoral Supervisor
• PhD in Sciences (Biochemistry) from the Universidade Federal do Paraná, Brazil (1987)
• Post-doctorate from the University of London, England (1991)
• Full Professor I at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

EXPERIMENTAL NEUROPROTECTION IN MODELS OF CEREBRAL ISCHEMIA AND RAQUIMEDULAR INJURY

Studies about mechanisms of cell death and neuroprotection in models of chronic neurological pathologies of great incidence and morbidity, such as cerebral ischemia in adults and in newborns or as spinal cord injuries, as well as in the process of senescence. We especially studied neuroplasticity, glial function and inflammatory modulation, with the final outcome of functional, cognitive or motor recovery following pharmacological treatments with innovative and non-pharmacological molecules such as physical exercise, environmental stimulation and skill training.

Concentration Areas: Neurochemistry, Neuropharmacology, and Behaviour

Telefone - Dra. Carmem Juracy Silveira Gottfried   E-mail - Dra. Carmem Juracy Silveira Gottfried   Lattes - Dra. Carmem Juracy Silveira Gottfried

Dra. Carmem Juracy Silveira Gottfried

Curriculum

• Research Productivity Scholarship 1C | Master’s Advisor | Doctoral Advisor
• PhD in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Brazil (2000)
• Adjunct Professor IV at theUniversidade Federal do Rio Grande do Sul, Brazil

Research Line

DISORDERS OF THE AUTISM SPECTRE

Autism Spectrum Disorder (ASD) is a multifactorial neural development disorder with varying degrees of presentation, characterized by (1) changes in social communication and social interaction in multiple contexts and (2) repetitive behaviors, restricted activities and interests. One of the strengths of this line is the interchange of knowledge between clinical and basic research, together with the opening of space for discussion and training of other health professionals, particularly in clinical practice, in the search for innovative therapeutic strategies.

Concentration Areas: Neurochemistry, Neuropharmacology, and Behaviour

Telefone - Dra. Carmen Regla Vargas   E-mail - Dra. Carmen Regla Vargas   Lattes - Dra. Carmen Regla Vargas

Dra. Carmen Regla Vargas

Curriculum

• Research Productivity Scholarship 1C | Master’s Advisor | Doctoral Advisor
• PhD in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Brazil (2000)
• Post-doctorate from the Universidade Federal de Santa Maria, Brazil (2002)
• Adjunct Professor IV at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

OXIDATION STRESSES IN METABOLIC DISEASES

This research line aims to study the in vitro and in vivo effects of metabolites accumulated in metabolic diseases inherited under oxidative stress and inflammatory processes. For this, different parameters of oxidative stress in human and animal tissues will be investigated. Patients will be studied at diagnosis and throughout the treatment in order to better understand the pathophysiology of these diseases, as well as to evaluate the effect of the treatment of these pathologies on the parameters of oxidative damage and inflammation.

Concentration Areas: Innate Errors of the Metabolism

Telefone - Dr. Clarissa Severino Gama   Telefone - Dr. Clarissa Severino Gama   E-mail - Dr. Clarissa Severino Gama   Lattes - Dr. Clarissa Severino Gama

Dr. Clarissa Severino Gama

Curriculum

• 1D Research Productivity Scholarship | Master’s Advisor | Doctoral Advisor
• Doctorate in Medicine: Medical Sciences at the Universidade Federal do Rio Grande do Sul Brazil (2004)
• Adjunct Professor III at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

Neuroprogression in Severe Psychiatric Disorders

Investigate the biological underpinnings of the decline in cognition, physical health and functioning that takes place among patients with bipolar disorder and schizophrenia. The group has been studying biomarkers (systemic and brain imaging) and cognitive performance in order to understand the mechanisms to avoid disease progression and daily functioning decline; contributing to the notion that bipolar disorder and schizophrenia are systemic and progressive illnesses.

Concentration Areas: Neuroprogression, Behaviour, Psychopharmacology

Telefone - Dr. Clovis Milton Duval Wannmacher   E-mail - Dr. Clovis Milton Duval Wannmacher   Lattes - Dr. Clovis Milton Duval Wannmacher

Dr. Clovis Milton Duval Wannmacher

Curriculum

• Research Productivity Scholarship 1C | Master’s Advisor | Doctoral Supervisor
• PhD in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Brazil (1995)
• Full Professor at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

EXPERIMENTAL STUDIES IN INTEGRATED ERRORS OF AMINO ACID METABOLISM

Study of behavioral and metabolic changes in chemical models of innate errors of amino acid metabolism in rats: oxidative stress, phosphoryl transfer and protection by creatine and pyruvate.

Concentration Areas: Innate Errors of the Metabolism

Telefone - Dra. Cristiane Matté   E-mail - Dra. Cristiane Matté   Lattes - Dra. Cristiane Matté

Dra. Cristiane Matté

Curriculum

• Master’s Advisor | Doctoral Advisor
• PhD in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Brazil (2009)
• Adjunct Professor I at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

METABOLIC PROGRAMMING

Gestation is a critical period for the development and programming of the organism in formation, and can be altered by several factors, such as nutrition, hormones, stressors and physical exercise. Our objective is to evaluate the effect of these factors during maternal gestation in rats on behavioral and biochemical parameters in the central nervous system of pups. Study of behavioral and metabolic changes in chemical models of innate errors of amino acid metabolism in rats: oxidative stress, phosphoryl transfer and Protection by creatine and pyruvate.

Concentration Areas: Nutrition, Metabolism, Oxidative Stress

INNATE ERRORS OF THE METABOLISM

We seek to clarify the mechanisms of neuro and hepatotoxicity of compounds accumulated in Inborn Errors of Metabolism, as well as to identify therapeutic strategies aimed at preventing or reversing the damages caused by these compounds.

Concentration Areas: Innate Errors of the Metabolism

Telefone - Dr. Daniel Pens Gelain   E-mail - Dr. Daniel Pens Gelain   Lattes - Dr. Daniel Pens Gelain

Dr. Daniel Pens Gelain

Curriculum

• Research Productivity Scholarship 2 | Master’s Advisor | Doctoral Supervisor
• PhD in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Brazil (2008)
• Post-doctorate from the Universidade Federal do Rio Grande do Sul, Brazil (2010)
• Adjunct Professor I at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

REDOX-ACTIVE SIGNALING IN NERVOUS AND IMUNE SYSTEMS

To elucidate cell signaling mechanisms by which reactive species (free radicals) control processes of regulation in the cell cycle, neuronal function and modulation of the inflammatory response, in order to establish new therapeutic targets for neurodegenerative diseases and disorders related to pro-inflammatory conditions.

Concentration Area: Cellular Biology

Telefone - Dr. Diogo Lösch de Oliveira   E-mail - Dr. Diogo Lösch de Oliveira   Lattes - Dr. Diogo Lösch de Oliveira

Dr. Diogo Lösch de Oliveira

Curriculum

• Master’s Advisor | Doctoral Supervisor
• PhD in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Brazil (2008)
• Post-doctorate from the Universidade Federal do Rio Grande do Sul, Brazil (2010)
• Adjunct Professor I at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

MOLECULAR MECHANISMS IN NEURODEGENERATIVE DISEASES

Our research line studies the cellular and molecular mechanisms involved in neurodegenerative diseases, emphasizing the role of the glutamatergic system in the excessive stimulation of ion channels and signaling pathways in nerve cells. In addition, the laboratory seeks to develop and evaluate new pharmacological neuroprotection strategies.

Concentration Areas: Neurochemestry, Neuropharmacology, and Behaviour/p>

Telefone - Dr. Diogo Onofre Gomes de Souza   E-mail - Dr. Diogo Onofre Gomes de Souza   Lattes - Dr. Diogo Onofre Gomes de Souza

Dr. Diogo Onofre Gomes de Souza

Curriculum

• Research Productivity Scholarship 1A | Master’s Advisor | Doctoral Supervisor
• PhD in Biochemistry from the Universidade Federal do Rio Janeiro, Brazil (1980)
• Post-doctorate from the University of London, England (1981)
• Full Professor at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

CEREBRAL INJURY/NEUROPROTECTION: INTERACTION BETWEEN EXTRACELLULAR GUANOSIN AND THE GLUTAMATERGIC SYSTEM: POSSIBLE GUANOSINE ROLE AS NEUROPROTECTOR

To identify the cerebral mechanisms involved in the neuroprotective effects of guanosine against glutamatergic excitocity. To identify possible therapeutic relevance of the neuroprotective effects of guanosine.

Concentration Areas: Neurochemestry, Neuropharmacology, and Behaviour

Telefone - Dr. Eduardo Rigon Zimmer   E-mail - Dr. Eduardo Rigon Zimmer   Lattes - Dr. Eduardo Rigon Zimmer   Website - Dr. Eduardo Rigon Zimmer

Dr. Eduardo Rigon Zimmer

Curriculum

• Research Productivity Scholarship Level 2 | Master’s Advisor | Doctoral Supervisor
• PhD in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Brazil (2015)
• Post-doctorate from the Universidade Federal do Rio Grande do Sul, Brazil (2016)
• Adjunct Professor at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

NEUROIMAGING IN BRAIN DISEASES

My research group uses refined neuroimaging techniques via Positron Emission Tomography (PET) to understand pathophysiological events in Alzheimer’s Disease. Our approach has a high translational character, as our studies combine image data in experimental models with data from clinical images. Currently, we have 5 well-defined lines of research: 1) Neuron-glia communication in Alzheimer’s Disease; 2) Metabolic networks in Alzheimer’s Disease; 3) Recognition of patterns in Alzheimer’s disease based on algorithms; 4) Development of a platform for the identification of beta-amyloid anti-oligomer compounds; and 5) Modifiable risk factors in Alzheimer’s disease.

Concentration Area:
Neurochemistry, Neuropharmacology and Behavior

Telefone - Dr. Fábio Klamt   E-mail - Dr. Fábio Klamt   Lattes - Dr. Fábio Klamt

Dr. Fábio Klamt

Curriculum

• 1D Research Productivity Scholarship | Master’s Advisor | Doctoral Supervisor
• PhD in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Brazil (2003)
• Post-Doctorate by the Center of Drug Evaluation and Research, Food and Drug Administration, United States (2006)
• Associate Professor I at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

USE OF THE DIFFERENTIATED HUMAN NEUROBLASTOMAN LINEAGE SH-SY5Y AS AN ALTERNATIVE MODEL IN NEUROSCIENCES

The nervous system is pre-disposed to oxidative stress, and it is well established that many neurodegenerative diseases present this pathophysiological mechanism in common. But the molecular mechanisms of degeneration are not elucidated. For this reason, cellular models are important and use neurotoxins to mimic neurodegeneration. Our laboratory characterized an in vitro dopaminergic cell model through cellular differentiation of SH-SY5Y neuroblastoma induced by retinoic acid for 7 days. These cells present morphological and biochemical characteristics (presence of neurites and increased immunocontent of markers of neuronal differentiation) of a dopaminergic neuron. Since the production of reactive species is important in neurodegeneration, the search for and description of new antioxidant molecules with neuroprotective potential are therapeutic targets.

STUDY OF BIOMARKERS IN LUNG CARCINOMA

Worldwide, lung carcinoma has the highest mortality rate among malignant neoplasms. Despite advances in lung cancer studies, improvement in the diagnosis, prognosis and treatment of patients are still objectives to be achieved. The identification of biomarkers constitutes a possibility of staging aid and an important step in individualized therapy and, ultimately, in increasing patient survival. This line of research seeks to characterize the prognostic and predictive potential of several biomarkers for lung carcinomas through cell lineage studies, database meta-analysis and in patient biopsies.o.

Concentration Areas: Cellular Biology

Telefone - Dr. Fabrício Figueiró   E-mail - Dr. Fabrício Figueiró   Lattes - Dr. Fabrício Figueiró

Dr. Fabrício Figueiró

Curriculum

• Master’s Advisor | Doctoral supervisor
• PhD in Biochemistry from the Universidade Federal do Rio Grande do Sul, Brazil (2015)
• Post-Doctorate in Biochemistry from the Universidade Federal do Rio Grande do Sul, Brazil (2017).
• Adjunct Professor at the Universidade Federal do Rio Grande do Sul, Brazil.

Research Line

MODULATION OF THE IMMUNE SYSTEM IN CANCER

In this line of research, we seek to understand and modulate the immune system in solid tumors (gliomas, medulloblastomas and bladder cancer) in three main aspects:
I. Participation of the purinergic system in immune modulation, mainly by ATP, through binding to P2 receptors, and by adenosine, through binding to P1 receptors.
II. Participation of extracellular vesicles in immune modulation, mainly through the effects performed by exosomes.
III. Evaluation of pharmacological interventions in preclinical cancer models, involving the immune system, the purinergic system and / or extracellular vesicles.

Concentration Area:
Cellular Biology

Telefone - Dra. Fátima Theresinha Costa Rodrigues Guma   E-mail - Dra. Fátima Theresinha Costa Rodrigues Guma   Lattes - Dra. Fátima Theresinha Costa Rodrigues Guma

Dra. Fátima Theresinha Costa Rodrigues Guma

Curriculum

• Research Productivity Scholarship 2 | Master’s Advisor | Doctoral Advisor
• PhD in Sciences (Biochemistry) from the Universidade Federal do Paraná, Brazil (1992)
• Full Professor at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

STUDY OF THE MECHANISMS OF DIFFERENTIATION, PROLIFERATION AND CELL VIABILITY

The study of mechanisms that induce or impede differentiation and proliferation or alter cell viability are important both for tumor growth control and for enhancing the use of stem cells in tissue regeneration. In this sense it is relevant to investigate compounds with the potential to become adjuvants in conventional therapies. The recognition of pluripotency of hepatic stellate cells (HSC) has increased the interest about their part in liver regeneration, therefore studies to clarify the mechanisms involved in the phenotypic modulation of these cells are of great interest for the development of new forms of disease control. In this sense, we have developed studies aiming to find the effects of overexpression and gene silencing, such as Caveolina1 (Cav-1), Sirt-1 and PPARg in a HSC model. Using as a model lineages of transformed cells, hepatic stellate cells and derived adipose stem cells, we propose to analyze the effects of compounds such as: doxazosin, resveratrol, ogama-orizanol and Thuyaoccidentalis extract on the viability, proliferation and / Or the differentiation of these cells.

Concentration Areas: Cellular Biology

Telefone - Dr. Guilhian Leipnitz   E-mail - Dr. Guilhian Leipnitz   Lattes - Dr. Guilhian Leipnitz

Dr. Guilhian Leipnitz

Curriculum

• Research Productivity Scholarship 2 | Master’s Advisor | Doctoral Supervisor
• PhD in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Brazil (2009)
• Post-doctorate from the Universidade Federal do Rio Grande do Sul, Brazil (2010)
• Adjunct Professor at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

RESEARCH OF PHYSIOPATHOLOGICAL MECHANISMS INVOLVED ON TISSUE DAMAGE IN ORGANIC ACIDEMIAS AND AMINOACIDOPATHIES

This research aims to evaluate possible pathophysiological mechanisms involved in tissue damage, mainly neurological, observed in aminoacidopathies and organic acidemias. We used experimental models in vivo and in vitro to evaluate the effects of metabolites that accumulate in these diseases on energy and redox homeostasis, mitochondrial function and cell signaling pathways. It also studies the effects of antioxidant compounds, energetic substrates and Glutamatergic antagonists in animal models in vitro and in vivo of hereditary metabolic diseases.

Concentration Areas: Innate Errors in the Metabolism

Telefone - Dra. Jade de Oliveira   E-mail - Dra. Jade de Oliveira

Dra. Jade de Oliveira

Currículo

• Master’s Advisor / Doctoral Advisor
• PhD in Biochemistry from the Universidade Federal do Santa Catarina, Brazil (2015)
• Post-Doctorate in Neuroscience from the Universidade Federal de Santa Catarina, Brazil (2016)
• Adjunct Professor at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

METABOLIC DISEASES AND THE DEVELOPMENT OF NEUROPATHOLOGIES. STUDY OF POSSIBLE THERAPEUTIC STRATEGIES.

A worldwide phenomenon is the significant increase in life expectancy, and consequently in the number of individuals affected by neurodegenerative diseases, such as those that represent the main causes of dementia, Alzheimer’s and Parkinson’s diseases. In recent years, evidence has shown the relationship between metabolic diseases, such as hypercholesterolemia and obesity, and the development of these neuropathologies. Thus, the study of therapeutic interventions for metabolic diseases is of particular importance, in view of the high prevalence of these pathologies in the world population, as well as the relevance of their consequences. In this sense, our goal is to evaluate neuroprotection strategies to prevent or mitigate the effects of metabolic diseases on brain structures.

Concentration Areas: Neurochemistry, Neuropharmacology and Behavior

Telefone - Dr. José Cláudio Fonseca Moreira   E-mail - Dr. José Cláudio Fonseca Moreira   Lattes - Dr. José Cláudio Fonseca Moreira

Dr. José Cláudio Fonseca Moreira

Curriculum

• Research Productivity Scholarship 1A | Master’s Advisor | Doctoral Supervisor
• PhD in Sciences (Biochemistry) from the Universidade Federal do Paraná, Brazil (1995)
• Full Professor at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

REACTIVE SPECIES AND THEIR EFFECTS ON BIOLOGICAL SYSTEMS

This research aims to evaluate of the role of reactive species as markes in the most important biochemical processes of biological systems in both normal and pathological physiological processes, as well as their role in cell differentiation and growth. Search and evaluation of natural or synthetic compounds with active redox properties.

Concentration Areas: Nutrition, Metabolism, Oxidative Stress

BIOINFORMATICS AND SYSTEMS BIOLOGY APPLIED TO BIOCHEMISTRY

Use of bioinformatics and systems biology tools for problem solving in biochemistry. Creation of new software for evaluation of boanks of gene expression and proteomics.

Concentration Areas: Cellular Biology

Telefone - Dra. Lisiane de Oliveira Porciúncula   E-mail - Dra. Lisiane de Oliveira Porciúncula   Lattes - Dra. Lisiane de Oliveira Porciúncula

Dra. Lisiane de Oliveira Porciúncula

Curriculum

• Research Productivity Scholarship 2 | Master’s Advisor | Doctoral Supervisor
• PhD in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Brazil (2003)
• Post-Doctorate by the University of Coimbra, Portugal (2005)
• Adjunct Professor III at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

STUDIES ON THE PURINERGETIC SYSTEM

Our research aims to understand the role of adenosine and its receptors in diseases that affect the brain during and after its development. Our group investigates the impact of caffeine administration (a non-selective antagonist of adenosine receptors) on the normal development of the brain and experimental models of neurodevelopmental diseases, evaluating behavioral, metabolic and electrophysiological changes.

Concentration Areas: Neurochemestry, Neuropharmacology, and Behaviour

Telefone - Dr. Luis Valmor Cruz Portela   E-mail - Dr. Luis Valmor Cruz Portela   Lattes - Dr. Luis Valmor Cruz Portela

Dr. Luis Valmor Cruz Portela

Curriculum

• Research Productivity Scholarship 2 | Master’s Advisor | Doctoral Supervisor
• PhD in Biological Sciences (Biochemistry) from the Universidade Federal do Rio Grande do Sul, Brazil (2002)
• Adjunct Professor III at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

NEURODEGENERATION MECHANISMS AND BIOMARKERS IN NEUROTRAUMA

Cranio-Encephalic Trauma (TBI) can lead to premature death, cognitive and neuropsychiatric disorders, and even activate neurodegeneration mechanisms. Our laboratory tries to unravel the molecular and cellular mechanisms involved in these changes using experimental models and studies in patients. In addition, we are interested in developing innovative neuroprotection strategies.

Concentration Areas: Neurochemestry, Neuropharmacology, and Behaviour

Telefone - Dra. Márcia Kauer Sant’Anna   E-mail - Dra. Márcia Kauer Sant’Anna   Lattes - Dra. Márcia Kauer Sant’Anna

Dra. Márcia Kauer Sant’Anna

Curriculum

• 1D Research Productivity Scholarship | Master’s Advisor | Doctoral Supervisor
• PhD in Biological Sciences (Biochemistry) from the Universidade Federal do Rio Grande do Sul, Brazil (2007)
• Postdoctoral fellow at the University of British Columbia, Canada (2009)
• Adjunct Professor III at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

FISIOPATHOLOGY OF MOOD DISORDERS

The pathophysiology of mood disorders has not yet been fully elucidated, however, major advances in its clarification are being reported. Among the several studies carried out in recent years, the most significant findings are concentrated primarily in biological pathways related to neurotrophins, inflammation and oxidative stress, which are linked to neuroplasticity. In order to investigate the biochemical and molecular mechanisms involved in the pathophysiology of psychiatric disorders, the research group has used patient biological samples and experimental models (cell culture and animal models) together with techniques such as immunoassays, flow cytometry and confocal microscopy.

Concentration Areas: Neurochemestry, Neuropharmacology, and Behaviour

Telefone - Dr. Marcos Roberto de Oliveira   E-mail - Dr. Marcos Roberto de Oliveira   Lattes - Dr. Marcos Roberto de Oliveira

Dr. Marcos Roberto de Oliveira

Curriculum

• Research Productivity Scholarship 2 | Master’s Advisor | Doctoral Supervisor
• PhD in Biological Sciences (Biochemistry) from the Universidade Federal do Rio Grande do Sul, Brazil (2010)
• Adjunct Professor A-I at theUniversidade Federal do Rio Grande do Sul, Brazil

Research Line

Mitochondrial therapy based on natural molecules

Mitochondria are the main organelles responsible for the synthesis of adenosine triphosphate (ATP) in human cells. They are also involved in calcium metabolism and the control of cellular fate, as they are central to the process called apoptosis. Different metabolic pathways occur wholly or partially in these organelles. Therefore, mitochondrial dysfunctions are the cause of cell death in several diseases. In this context, we investigated, in this line of research, natural molecules, mainly of plant origin, as agents to promote mitochondrial protection in experimental models in vitro, ex vivo, and in vivo.

Concentration Areas:
Metabolism and Bioenergetics and Neurochemistry

Telefone - Dra. Maria Elisa Calcagnotto   E-mail - Dra. Maria Elisa Calcagnotto   Lattes - Dra. Maria Elisa Calcagnotto

Dra. Maria Elisa Calcagnotto

Curriculum

• Master’s Advisor | Doctoral Advisor
• PhD in Neurology / Neuroscience from the Universidade Federal de São Paulo, Brazil (2006)
• Post-Doctorate in Neurophysiology by the Montreal Neurological Insitute – McGill University, Canada (2000)
• Post-Doctorate in Neurophysiology from the University of California in San Francisco (UCSF), United States (2005)
• Post-Doctorate in Neurophysiology at the Universidade Federal de São Paulo, Brazil (2008)
• Post-Doctorate in Neurophysiology at the Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), Spain (2010)
• Post-Doctorate in Neurochemistry – Neurophysiology at the Universidade Federal do Rio Grande do Sul, Brazil (2013)
• Adjunct Professor at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

BASIC MECHANISMS OF EPILEPSY>

Our research focuses on the intrinsic, synaptic and molecular mechanisms that regulate neuronal excitability and the involvement of the GABAergic system in epileptogenesis. Studying animal models of epilepsy and tissue obtained from patients undergoing surgery for difficult-to-control epilepsy, we hope to gain a better understanding of the cellular events underlying epileptic activity. The techniques used include in vivo electrophysiological records of brain and in vitro oscillations of cell membrane properties and synaptic function in tissue slices and cell culture; Morphological studies of neural network structure and expression of proteins by immunohistochemistry; And pharmacological analyzes.

Concentration Areas: Neurochemestry, Neuropharmacology, and Behaviour

Telefone - Dra. Maria Luiza Saraiva Pereira   E-mail - Dra. Maria Luiza Saraiva Pereira   Lattes - Dra. Maria Luiza Saraiva Pereira

Dra. Maria Luiza Saraiva Pereira

Curriculum

• Research Productivity Scholarship 2 | Master’s Advisor | Doctoral Advisor
• PhD in Molecular Genetics from the University of London, England (1994)
• Post-doctorate from the University of Oxford, England (1995)
• Full Professor at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

CELLULAR AND MOLECULAR BIOLOGY OF HEREDITARY DISEASES

To evaluate variations in genes sequences associated with hereditary disorders and the effect of these changes in the treatment of these patients, when treatment is available. The identification of new targets for the development of therapies is another focus of the line of research. To identify and evaluate the effect of nucleotide replications in patients with neurodegenerative diseases.

Concentration Areas: Cellular Biology

Telefone - Dra. Marina Concli Leite   E-mail - Dra. Marina Concli Leite   Lattes - Dra. Marina Concli Leite

Dra. Marina Concli Leite

Curriculum

• Master’s Advisor | Doctoral Advisor
• PhD in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Brazil (2010)
• Adjunct Professor I at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

DIET, ADIPOCINES AND NEUROPROTECTION

The type of diet affects metabolism, including that of the CNS. Thus diets “diabetes-genics”, by effect of glucose or its derivatives (methylglyoxal or AGE) can cause damage to the CNS. On the other hand, caloric restriction and ketogenic diet have been proposed as protectors in certain neuropsychiatric diseases. Here we investigate endocrine mediators (eg, insulin, adipokines) and possible molecular targets and mechanisms of damage or protection to the CNS and peripheral (hepatic, renal and adipose) tissues in In vivo models and cell cultures.

Concentration Areas: Nutrition, Metabolism, Oxidative Stress

Telefone - Dr. Moacir Wajner   E-mail - Dr. Moacir Wajner   Lattes - Dr. Moacir Wajner

Dr. Moacir Wajner

Curriculum

• Research Productivity Scholarship 1A | Master’s Advisor | Doctoral Supervisor
• PhD in Basic Sciences from the University of Newcastle Upon Tyne, England (1982)
• Post-doctorate from Universität Heidelberg (Ruprecht-Karls), Germany (1993)
Molecular, Enzymology and Chemistry of Macromolecules
• Full Professor at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

STUDIES OF THE TOXICITY MECHANISMS OF THE ACCUMULATED METABOLITICS IN ORGANIC ACIDEMICS AND DEFECTS ON OXIDATION OF FATTY ACIDS

To study the tissue toxicity mechanisms (brain, heart, liver and skeletal muscle) of carboxylic acids and their accumulated derivatives in organic acidemia, fatty acid oxidation defects and aminoacidopathies on redox homeostasis and mitochondrial energetics, as well as on the glutamatergic system (Brain) aiming to clarify the pathophysiology of these diseases and make possible new therapeutic strategies for them.

Concentration Areas: Innate Errors of the Metabolism

Telefone - Dra. Rachel Krolow Santos Silva Bast   E-mail - Dra. Rachel Krolow Santos Silva Bast   Lattes - Dra. Rachel Krolow Santos Silva Bast

Dra. Rachel Krolow Santos Silva Bast

Curriculum

• Master’s Advisor | Doctoral Advisor
• PhD in Biochemistry from the Universidade Federal do Rio Grande do Sul, Brazil (2013)
• Post-Doctorate in Biochemistry from the Universidade Federal do Rio Grande do Sul, Brazil (2015)
• Expertise in Biochemistry and Neuroscience
• Adjunct Professor at the Universidade Federal do Rio Grande do Sul, Brazil

Research Line

NEUROBIOLOGICAL PROGRAMMING OF FOOD BEHAVIOR

The consumption of different types of food during pregnancy or in early periods of life can program the metabolism and behavior of the adult animal. Early exposure to diets high in fat and / or sugar has demonstrated changes in the biochemical pathways that control homeostatic and hedonic eating behavior. Changes in hormones: leptin, adiponectin, ghrelin and insulin, have been observed in studies with animal models and also in humans, being one of the study objectives of the group. The study of biochemical markers related to neurogenesis and plasticity in different brain structures is also the focus of the study. With regard to behavior, the group studies possible changes caused by the early exposure of different types of food on food preference, memory, depression and anxiety in adulthood. In addition, the study of foods with a protective potential for behavior and for peripheral and central metabolism has also been studied in the laboratory.

Concentration Areas: Nutrition, Metabolism and Oxidative Stress